Characterizing the protein content in tears for early detection of disease

M. Antoine, P. Demirev, H. Le, A. Behrens, J. Castro

Research output: Contribution to journalArticlepeer-review


A team of biomedical researchers have developed new method using mass spectrometry and advanced proteomics to identify wellness biomarkers and pathogen biomarkers present in tear fluid obtained from healthy and diseased animals. Tear specimens were suitable specimens for rapid diagnosis due to their clean background and non-invasive collection. The overall objective of the research effort was to determine the feasibility of detecting and identifying biomarkers that indicated pathogen exposure and infection in tear fluid in real time. The protein content of tear samples was established by advanced analytical proteomics technologies.

Original languageEnglish (US)
Pages (from-to)228-229
Number of pages2
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Issue number3
StatePublished - 2010

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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