Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

Ha Kyu Jeong, Kyunghwa Han, Jinyuan Zhou, Yansong Zhao, Yoon Seong Choi, Seung Koo Lee, Sung Soo Ahn

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The aim of this study was to characterize amide proton transfer (APT)-weighted signals in acute and subacute haemorrhage brain lesions of various underlying aetiologies. Methods: Twenty-three patients with symptomatic haemorrhage brain lesions including tumorous (n = 16) and non-tumorous lesions (n = 7) were evaluated. APT imaging was performed and analyzed with magnetization transfer ratio asymmetry (MTRasym). Regions of interest were defined as the enhancing portion (when present), acute or subacute haemorrhage, and normal-appearing white matter based on anatomical MRI. MTRasym values were compared among groups and components using a linear mixed model. Results: MTRasym values were 3.68 % in acute haemorrhage, 1.6 % in subacute haemorrhage, 2.65 % in the enhancing portion, and 0.38 % in normal white matter. According to the linear mixed model, the distribution of MTRasym values among components was not significantly different between tumour and non-tumour groups. MTRasym in acute haemorrhage was significantly higher than those in the other regions regardless of underlying pathology. Conclusions: Acute haemorrhages showed high MTRasym regardless of the underlying pathology, whereas subacute haemorrhages showed lower MTRasym than acute haemorrhages. These results can aid in the interpretation of APT imaging in haemorrhage brain lesions. Key Points: • Acute haemorrhages show significantly higher MTRasymvalues than subacute haemorrhages. • MTRasymis higher in acute haemorrhage than in enhancing tumour tissue. • MTRasymin haemorrhage does not differ between tumorous and non-tumorous lesions.

Original languageEnglish (US)
Pages (from-to)1577-1584
Number of pages8
JournalEuropean radiology
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Amide proton transfer imaging
  • Brain neoplasms
  • Cerebral haemorrhage
  • Magnetic resonance imaging
  • Magnetization transfer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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