Characterization of vestibulopathy in individuals with type 2 diabetes mellitus

Bryan Ward, Angela Wenzel, Rita R. Kalyani, Yuri Agrawal, Allen L. Feng, Michael J Polydefkis, Howard S. Ying, Michael C Schubert, M. Geraldine Zuniga, Charles Coleman Della Santina, John P Carey

Research output: Contribution to journalArticle


Objective. Previous observational studies suggest higher rates of vestibular dysfunction among patients with type 2 diabetes mellitus (DM) compared with those without diabetes. This study aims to functionally localize vestibular dysfunction in adults with type 2 DM. Study Design. Prospective cohort study. Setting. Tertiary academic medical center. Subjects and Methods. Adults 50 years of age and older with ≥10-year history of type 2 DM were recruited (December 2011-February 2013, n = 25). Vestibular function was assessed by cervical and ocular vestibular-evoked myogenic potentials (VEMPs), testing the saccule and utricle, respectively. Head thrust dynamic visual acuity testing assessed semicircular canal (SCC) function in all canal planes. Results were compared with nondiabetic age-matched controls (n = 25). Results. Subjects were 64.7 ± 7.6 years old, were 40% female, and had a mean hemoglobin A1c of 8.3% ± 1.7%. SCC dysfunction was more common than otoconial organ dysfunction, with 70% of subjects with DM demonstrating impaired performance of at least 1 SCC (DlogMAR ≥0.18) and 50% demonstrating otoconial organ impairment (absent ocular VEMP and/or cervical VEMP). Adults with type 2 DM had poorer lateral and superior SCC performance (P

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Issue number1
StatePublished - Jul 3 2015



  • diabetes
  • inner ear
  • vestibular

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

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