Characterization of type I receptors for transforming growth factor-β and activin

Peter Ten Dijke, Hidetoshi Yamashita, Hidenori Ichijo, Petra Franzén, Marikki Laiho, Kohei Miyazono, Carl Henrik Heldin

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Abstract

Transforming growth factor-β (TGF-β) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-β and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-β type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-β and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-β type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalScience
Volume264
Issue number5155
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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ASJC Scopus subject areas

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Cite this

Ten Dijke, P., Yamashita, H., Ichijo, H., Franzén, P., Laiho, M., Miyazono, K., & Heldin, C. H. (1994). Characterization of type I receptors for transforming growth factor-β and activin. Science, 264(5155), 101-104. https://doi.org/10.1126/science.8140412