TY - JOUR
T1 - Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization
AU - Taniwaki, Masafumi
AU - Speicher, Michael R.
AU - Lengauer, Christoph
AU - Jauch, Anna
AU - Popp, Susanne
AU - Cremer, Thomas
PY - 1993/10/15
Y1 - 1993/10/15
N2 - A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).
AB - A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).
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U2 - 10.1016/0165-4608(93)90175-L
DO - 10.1016/0165-4608(93)90175-L
M3 - Article
C2 - 8242604
AN - SCOPUS:0027368174
VL - 70
SP - 99
EP - 102
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -