Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Masafumi Taniwaki; Michael R. Speicher; Christoph Lengauer; Anna Jauch; Susanne Popp; Thomas Cremer

doi:10.1016/0165-4608(93)90175-L

Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Masafumi Taniwaki, Michael R. Speicher, Christoph Lengauer, Anna Jauch, Susanne Popp, Thomas Cremer

Research output: Contribution to journal › Article

Abstract

A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).

Original language	English (US)
Pages (from-to)	99-102
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(93)90175-L
Publication status	Published - Oct 15 1993
Externally published	Yes

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ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

Cite this

Taniwaki, M., Speicher, M. R., Lengauer, C., Jauch, A., Popp, S., & Cremer, T. (1993). Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization. Cancer Genetics and Cytogenetics, 70(2), 99-102. https://doi.org/10.1016/0165-4608(93)90175-L

Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization. / Taniwaki, Masafumi; Speicher, Michael R.; Lengauer, Christoph; Jauch, Anna; Popp, Susanne; Cremer, Thomas.

In: Cancer Genetics and Cytogenetics, Vol. 70, No. 2, 15.10.1993, p. 99-102.

Research output: Contribution to journal › Article

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abstract = "A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).",

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10.1016/0165-4608(93)90175-L