Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Masafumi Taniwaki, Michael R. Speicher, Christoph Lengauer, Anna Jauch, Susanne Popp, Thomas Cremer

Research output: Contribution to journalArticle

Abstract

A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume70
Issue number2
DOIs
Publication statusPublished - Oct 15 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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