Characterization of toxicokinetics and toxicodynamics with linear systems theory: Application to lead-associated cognitive decline

Jonathan M. Links; Brian S. Schwartz; David Simon; Karen Bandeen-Roche; Walter F. Stewart

doi:10.1289/ehp.01109361

Characterization of toxicokinetics and toxicodynamics with linear systems theory: Application to lead-associated cognitive decline

Jonathan M. Links, Brian S. Schwartz, David Simon, Karen Bandeen-Roche, Walter F. Stewart

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We present a theoretical approach to analysis of toxicokinetics and toxicodynamics using linear systems theory. In our approach, we define two impulse response functions that characterize the kinetic behavior of an environmental agent in the body and the dynamic time-course behavior of its effect on the body. This approach provides a formalism for understanding the relation among exposure, dose, and cumulative biologically effective dose and for understanding the implications of an effect time-course on cross-sectional and longitudinal data analyses. We use lead-associated cognitive decline as a specific example where the approach may be applied.

Original language	English (US)
Pages (from-to)	361-368
Number of pages	8
Journal	Environmental health perspectives
Volume	109
Issue number	4
DOIs	https://doi.org/10.1289/ehp.01109361
State	Published - 2001

Keywords

Bone lead
Exposure assessment
Linear systems model
Toxicodynamics
Toxicokinetics

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1289/ehp.01109361

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AU - Simon, David

AU - Bandeen-Roche, Karen

AU - Stewart, Walter F.

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AB - We present a theoretical approach to analysis of toxicokinetics and toxicodynamics using linear systems theory. In our approach, we define two impulse response functions that characterize the kinetic behavior of an environmental agent in the body and the dynamic time-course behavior of its effect on the body. This approach provides a formalism for understanding the relation among exposure, dose, and cumulative biologically effective dose and for understanding the implications of an effect time-course on cross-sectional and longitudinal data analyses. We use lead-associated cognitive decline as a specific example where the approach may be applied.

KW - Bone lead

KW - Exposure assessment

KW - Linear systems model

KW - Toxicodynamics

KW - Toxicokinetics

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JO - Environmental health perspectives

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IS - 4

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Characterization of toxicokinetics and toxicodynamics with linear systems theory: Application to lead-associated cognitive decline

Abstract

Keywords

ASJC Scopus subject areas

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