Characterization of toxicokinetics and toxicodynamics with linear systems theory: Application to lead-associated cognitive decline

Jonathan M. Links, Brian S. Schwartz, David Simon, Karen Bandeen-Roche, Walter F. Stewart

Research output: Contribution to journalArticle

Abstract

We present a theoretical approach to analysis of toxicokinetics and toxicodynamics using linear systems theory. In our approach, we define two impulse response functions that characterize the kinetic behavior of an environmental agent in the body and the dynamic time-course behavior of its effect on the body. This approach provides a formalism for understanding the relation among exposure, dose, and cumulative biologically effective dose and for understanding the implications of an effect time-course on cross-sectional and longitudinal data analyses. We use lead-associated cognitive decline as a specific example where the approach may be applied.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalEnvironmental health perspectives
Volume109
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Bone lead
  • Exposure assessment
  • Linear systems model
  • Toxicodynamics
  • Toxicokinetics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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