Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography

Xing Liang, Kang-Hsin Wang, Timothy C. Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photodynamic therapy (PDT) is an important treatment modality for localized diseases such as prostate cancer. In prostate PDT, light distribution is an important factor because it is directly related to treatment efficacy. During PDT, light distribution is determined by tissue optical property distributions (or heterogeneity). In this study, an interstitial diffuse optical tomography (iDOT) method was used to characterize optical properties in tissues. Optical properties (absorption and reduced scattering coefficients) of the prostate gland were reconstructed by solving the inverse problem using an adjoint model based on diffusion equation using a modified matlab public user code NIRFAST. In the modified NIRFAST method, linear sources were modeled for the reconstruction. Cross talking between absorption coefficients and reduced scattering coefficients were studied to have minimal effect, and a constrained optical property method (set either absorption coefficient or reduced scattering coefficient to be homogeneous) is also studied. A prostate phantom with optical anomalies was used to verify the iDOT method. The reconstructed results were compared with the known optical properties, and the spatial distribution of optical properties for this phantom was successfully reconstructed.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8210
DOIs
StatePublished - 2012
Externally publishedYes
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI - San Francisco, CA, United States
Duration: Jan 21 2012Jan 22 2012

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI
CountryUnited States
CitySan Francisco, CA
Period1/21/121/22/12

Fingerprint

Optical Tomography
Photodynamic therapy
Optical tomography
Photochemotherapy
Prostate
therapy
interstitials
Optical properties
tomography
Tissue
optical properties
scattering coefficients
Scattering
Light
absorptivity
prostate gland
talking
Prostatic Neoplasms
Inverse problems
Spatial distribution

Keywords

  • Diffuse optical tomography
  • Optical property
  • Photodynamic therapy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Liang, X., Wang, K-H., & Zhu, T. C. (2012). Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8210). [82100C] https://doi.org/10.1117/12.908294

Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. / Liang, Xing; Wang, Kang-Hsin; Zhu, Timothy C.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8210 2012. 82100C.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liang, X, Wang, K-H & Zhu, TC 2012, Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8210, 82100C, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI, San Francisco, CA, United States, 1/21/12. https://doi.org/10.1117/12.908294
Liang X, Wang K-H, Zhu TC. Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8210. 2012. 82100C https://doi.org/10.1117/12.908294
Liang, Xing ; Wang, Kang-Hsin ; Zhu, Timothy C. / Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8210 2012.
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