Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection

Deogratius Ssemwanga, Nicole A. Doria-Rose, Andrew Redd, Andrea R. Shiakolas, Andrew F. Longosz, Rebecca N. Nsubuga, Billy N. Mayanja, Gershim Asiki, Janet Seeley, Anatoli Kamali, Amy Ransier, Samuel Darko, Michael P. Walker, Daniel Bruno, Craig Martens, Daniel Douek, Stephen F. Porcella, Thomas C Quinn, John R. Mascola, Pontiano Kaleebu

Research output: Contribution to journalArticle

Abstract

This report describes the identification of a genetically confirmed linked heterosexual human immunodeficiency virus (HIV) superinfection (HIV-SI) in a woman with chronic HIV infection who acquired a second strain of the virus from her husband. Serum neutralizing antibody (NAb) responses against their homologous and heterologous viruses, including the superinfecting strain, in the woman and her husband were examined before and after onset of HIV-SI. The woman displayed a moderately potent and broad anti-HIV NAb response prior to superinfection but did not possess NAb activity against the superinfecting strain. This case highlights the unique potential of linked HIV-SI studies to examine natural protection from HIV infection.

Original languageEnglish (US)
Pages (from-to)1530-1534
Number of pages5
JournalJournal of Infectious Diseases
Volume217
Issue number10
DOIs
StatePublished - Apr 23 2018

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Superinfection
Neutralizing Antibodies
Antibody Formation
HIV
Virus Diseases
Spouses
Viruses
Heterosexuality
Serum

Keywords

  • Africa
  • HIV Superinfection
  • NAb

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Ssemwanga, D., Doria-Rose, N. A., Redd, A., Shiakolas, A. R., Longosz, A. F., Nsubuga, R. N., ... Kaleebu, P. (2018). Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection. Journal of Infectious Diseases, 217(10), 1530-1534. https://doi.org/10.1093/infdis/jiy071

Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection. / Ssemwanga, Deogratius; Doria-Rose, Nicole A.; Redd, Andrew; Shiakolas, Andrea R.; Longosz, Andrew F.; Nsubuga, Rebecca N.; Mayanja, Billy N.; Asiki, Gershim; Seeley, Janet; Kamali, Anatoli; Ransier, Amy; Darko, Samuel; Walker, Michael P.; Bruno, Daniel; Martens, Craig; Douek, Daniel; Porcella, Stephen F.; Quinn, Thomas C; Mascola, John R.; Kaleebu, Pontiano.

In: Journal of Infectious Diseases, Vol. 217, No. 10, 23.04.2018, p. 1530-1534.

Research output: Contribution to journalArticle

Ssemwanga, D, Doria-Rose, NA, Redd, A, Shiakolas, AR, Longosz, AF, Nsubuga, RN, Mayanja, BN, Asiki, G, Seeley, J, Kamali, A, Ransier, A, Darko, S, Walker, MP, Bruno, D, Martens, C, Douek, D, Porcella, SF, Quinn, TC, Mascola, JR & Kaleebu, P 2018, 'Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection', Journal of Infectious Diseases, vol. 217, no. 10, pp. 1530-1534. https://doi.org/10.1093/infdis/jiy071
Ssemwanga, Deogratius ; Doria-Rose, Nicole A. ; Redd, Andrew ; Shiakolas, Andrea R. ; Longosz, Andrew F. ; Nsubuga, Rebecca N. ; Mayanja, Billy N. ; Asiki, Gershim ; Seeley, Janet ; Kamali, Anatoli ; Ransier, Amy ; Darko, Samuel ; Walker, Michael P. ; Bruno, Daniel ; Martens, Craig ; Douek, Daniel ; Porcella, Stephen F. ; Quinn, Thomas C ; Mascola, John R. ; Kaleebu, Pontiano. / Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection. In: Journal of Infectious Diseases. 2018 ; Vol. 217, No. 10. pp. 1530-1534.
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