Abstract
Abstract: N‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) selectively destroys neuronal cell bodies in the neuromelanin‐containing substantia nigra of humans and primates. We show that N‐methyl‐4‐phenylpyridine (MPP+), the active metabolite of MPTP, binds to neuromelanin with high affinity. This binding increases at higher pH and is displaced most potently by divalent cations and antimalarial drugs. MPP+ bound intracellularly to neuromelanin may be stored and released gradually, resulting in subsequent damage to neurons of the substantia nigra.
Original language | English (US) |
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Pages (from-to) | 653-658 |
Number of pages | 6 |
Journal | Journal of Neurochemistry |
Volume | 48 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1987 |
Keywords
- Neuromelanin
- Neurotoxicity
- N‐ Methyl‐4‐phenylpyridine
- N‐Methyl‐ 4 ‐ phenyl ‐1,2,3,6 ‐ tetrahydropyridine
- Parkinson's disease
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience