Characterization of [125I]SCH 23982 binding in human brain: Comparison with [3H]SCH 23390

Marc Laruelle, Anita Sidhu, Manual F. Casanova, Daniel R. Weinberger, Joel E. Kleinman

Research output: Contribution to journalArticlepeer-review

Abstract

We studied binding of [125I]SCH 23982 in two regions of human brain, the caudate and the dorsolateral prefrontal cortex. Binding characteristics of [125I]SCH 23982 and of the non-iodinated tritiated analogue, [3H]SCH 23390, were compared. In caudate, binding of [125I]SCH 23982 was consistent with binding to D1 dopamine receptors while in frontal cortex, [125I]SCH 23982 bound mostly to serotonergic 5HT2 receptors. In contrast to [3H]SCH 23390, no evidence of binding of [125I]SCH 23982 to D1 receptors could be found in human frontal cortex. This indicates that iodination of SCH 23390 induces a decrease in its relative D1 verus 5HT2 selectivity that prohibits the use of [125I]SCH 23982 to label D1 receptors in human cortex.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalNeuroscience Letters
Volume131
Issue number2
DOIs
StatePublished - Oct 14 1991
Externally publishedYes

Keywords

  • D dopamine receptor
  • Human brain
  • Receptor binding
  • SPECT imaging
  • [H]SCH 23390
  • [I]SCH 23982

ASJC Scopus subject areas

  • Neuroscience(all)

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