Characterization of spatial ordering of corneal stroma fibrils

D. E. Freund, P. Burlina, A. Banerjee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The quantitative characterization of the cornea's ultrastructure is an important component in clinical studies and ophthalmologic research for investigating various corneal pathologies such as Fuch's dystrophy, bullous keratopathy, and macular corneal dystrophy. The spatial ordering of the stromal fibrils is a good predictor of corneal transparency and light scattering. In this paper this structure is characterized by estimating the probability density function (PDF) associated with some features of the radial distribution function of fibrils seen in electron micrographs of the stroma. A method derived from the Support Vector Data Description (SVDD) is used to estimate this PDF. Experiments using electron micrographs of normal and swollen rabbit corneas are used to illustrate the approach.

Original languageEnglish (US)
Title of host publication2008 5th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, Proceedings, ISBI
Pages963-966
Number of pages4
DOIs
StatePublished - Sep 12 2008
Event2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI - Paris, France
Duration: May 14 2008May 17 2008

Publication series

Name2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Other

Other2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
CountryFrance
CityParis
Period5/14/085/17/08

Keywords

  • Corneal pathologies support vector methods
  • Fibril ordering
  • PDF estimation

ASJC Scopus subject areas

  • Biomedical Engineering

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