Characterization of Pulsed High Intensity Focused Ultrasound for Enhanced Drug and Gene Delivery

Anthony W. Kam, Honghui Wang, David Thomasson, Keyvan Farahani, King C.P. Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Within a certain range of parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of systemically administered drugs and plasmid DNA in tumors in mice. The sonicated tissue is not damaged by light microscopy. The mechanism for the enhanced delivery has not been shown conclusively and can include thermal, cavitational, and non-cavitation mechanical effects. In order to assess the effects of pulsed HIFU in a manner that allows for clinical translation, pulsed HIFU is performed within a magnetic resonance (MR) scanner. In this work, the thermal effect is evaluated with phase-shift MR thermometry in ex vivo chicken muscle. The thermal effect is small at the most common exposure parameters. In the future, non-thermal effects like permeability, diffusion, and elasticity changes will be evaluated with dynamic contrast enhanced MRI, diffusion-weighted MRI, and MR elastography. If changes in permeability, diffusion, and shear modulus are associated with pulsed HIFU enhanced delivery, then these parameters can be used as markers for optimization of pulsed HIFU enhanced delivery.

Original languageEnglish (US)
Title of host publicationTHERAPEUTIC ULTRASOUND
Subtitle of host publication5th International Symposium on Therapeutic Ultrasound
Pages563-567
Number of pages5
DOIs
StatePublished - May 8 2006
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: Oct 27 2005Oct 29 2005

Publication series

NameAIP Conference Proceedings
Volume829
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityBoston, MA
Period10/27/0510/29/05

Keywords

  • Drug and gene delivery
  • Focused ultrasound
  • MR thermometry

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Kam, A. W., Wang, H., Thomasson, D., Farahani, K., & Li, K. C. P. (2006). Characterization of Pulsed High Intensity Focused Ultrasound for Enhanced Drug and Gene Delivery. In THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound (pp. 563-567). (AIP Conference Proceedings; Vol. 829). https://doi.org/10.1063/1.2205537