Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study

Mihaela Pop, Maxime Sermesant, Tommaso Mansi, Eugene Crystal, Jay Detsky, Yuesong Yang, Paul Fefer, Elliot R. McVeigh, Alexander Dick, Nicholas Ayache, Graham A. Wright

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Arrhythmias are often associated with healing infarcts and could arise from the border zone of the scars. The main purpose of this work was to characterize the infarct scars using in vivo electro-anatomic CARTO maps (recorded in sinus rhythm) and high-resolution ex-vivo MR images in a porcine model of chronic infarct. The MR images were segmented into scar, peri-infarct and healthy ventricular tissue, and, in select slices, the results of segmentation were validated against histology. Further, the segmented volumes and associated fiber directions (derived from diffusion-weighted (DW) MRI as well as from synthetic models), were used as input to a simple two-variable mathematical model that calculates the propagation of depolarization waves and isochronal maps; and these isochronal maps were compared to the measured ones. We further correlated the size of the scar measured during the electrophysiology (EP) study with scar dimensions obtained from MRI using ex-vivo DW-MRI methods. Finally, we present preliminary results from a qualitative comparison between the scar delineation from ex vivo and in vivo MR images.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages1-10
Number of pages10
Volume5528
DOIs
StatePublished - 2009
Event5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009 - Nice, France
Duration: Jun 3 2009Jun 5 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5528
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009
CountryFrance
CityNice
Period6/3/096/5/09

Keywords

  • Cardiac MR imaging
  • Computer modeling
  • Electrophysiology

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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  • Cite this

    Pop, M., Sermesant, M., Mansi, T., Crystal, E., Detsky, J., Yang, Y., Fefer, P., McVeigh, E. R., Dick, A., Ayache, N., & Wright, G. A. (2009). Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5528, pp. 1-10). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5528). https://doi.org/10.1007/978-3-642-01932-6_1