Abstract
Two steps forward: The glycosylated aminocoumarin antibiotic novobiocin (1) is produced by. Streptomyces spheroides and inhibits the bacterial type II topoisomerase DNA gyrase. The sugar-tailoring enzymes NovP and NovN that catalyze the final two steps in novobiocin biosynthesis were overproduced in Escherichia coli and characterized as a methyltransferase and carbamoyltransferase, respectively.
Original language | English (US) |
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Pages (from-to) | 67-70 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 43 |
Issue number | 1 |
DOIs | |
State | Published - Dec 22 2004 |
Externally published | Yes |
Keywords
- Antibiotics
- Biosynthesis
- Enzymes
- Novobiocin
- Transferases
ASJC Scopus subject areas
- Catalysis
- General Chemistry