Abstract
The transgenic HIV-1 rat (Tg) is a commonly used neuroHIV model with documented neurologic/behavioral deficits. Using immunofluorescent staining of the Tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. We saw mild microglial activation in young Tg brains, but this decreased with age. There were no differences in neurogenesis potential suggesting a neurodegenerative rather than a neurodevelopmental process. Gp120 CSF levels exceeded serum gp120 levels in some animals, suggesting local viral protein production in the brain. Further probing of the pathophysiology underlying astrocytic injury in this model is warranted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-125 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 292 |
| DOIs | |
| State | Published - Mar 15 2016 |
| Externally published | Yes |
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Keywords
- Astrocytic loss
- HIV-1 transgenic rat
- Neuro-HIV
- Neuropathology
- Neurotoxicity
- Viral proteins
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Characterization of neuropathology in the HIV-1 transgenic rat at different ages. / Reid, William C.; Ibrahim, Wael G.; Kim, Saejeong J.; Denaro, Frank; Casas, Rafael; Lee, Dianne E.; Maric, Dragan; Hammoud, Dima A.
In: Journal of Neuroimmunology, Vol. 292, 15.03.2016, p. 116-125.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Characterization of neuropathology in the HIV-1 transgenic rat at different ages
AU - Reid, William C.
AU - Ibrahim, Wael G.
AU - Kim, Saejeong J.
AU - Denaro, Frank
AU - Casas, Rafael
AU - Lee, Dianne E.
AU - Maric, Dragan
AU - Hammoud, Dima A.
PY - 2016/3/15
Y1 - 2016/3/15
N2 - The transgenic HIV-1 rat (Tg) is a commonly used neuroHIV model with documented neurologic/behavioral deficits. Using immunofluorescent staining of the Tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. We saw mild microglial activation in young Tg brains, but this decreased with age. There were no differences in neurogenesis potential suggesting a neurodegenerative rather than a neurodevelopmental process. Gp120 CSF levels exceeded serum gp120 levels in some animals, suggesting local viral protein production in the brain. Further probing of the pathophysiology underlying astrocytic injury in this model is warranted.
AB - The transgenic HIV-1 rat (Tg) is a commonly used neuroHIV model with documented neurologic/behavioral deficits. Using immunofluorescent staining of the Tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. We saw mild microglial activation in young Tg brains, but this decreased with age. There were no differences in neurogenesis potential suggesting a neurodegenerative rather than a neurodevelopmental process. Gp120 CSF levels exceeded serum gp120 levels in some animals, suggesting local viral protein production in the brain. Further probing of the pathophysiology underlying astrocytic injury in this model is warranted.
KW - Astrocytic loss
KW - HIV-1 transgenic rat
KW - Neuro-HIV
KW - Neuropathology
KW - Neurotoxicity
KW - Viral proteins
UR - http://www.scopus.com/inward/record.url?scp=84960849299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960849299&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2016.01.022
DO - 10.1016/j.jneuroim.2016.01.022
M3 - Article
VL - 292
SP - 116
EP - 125
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -