Characterization of neuropathology in the HIV-1 transgenic rat at different ages

William C. Reid; Wael G. Ibrahim; Saejeong J. Kim; Frank Denaro; Rafael Casas; Dianne E. Lee; Dragan Maric; Dima A. Hammoud

doi:10.1016/j.jneuroim.2016.01.022

Characterization of neuropathology in the HIV-1 transgenic rat at different ages

William C. Reid, Wael G. Ibrahim, Saejeong J. Kim, Frank Denaro, Rafael Casas, Dianne E. Lee, Dragan Maric, Dima A. Hammoud

School of Medicine

Research output: Contribution to journal › Article

Abstract

The transgenic HIV-1 rat (Tg) is a commonly used neuroHIV model with documented neurologic/behavioral deficits. Using immunofluorescent staining of the Tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. We saw mild microglial activation in young Tg brains, but this decreased with age. There were no differences in neurogenesis potential suggesting a neurodegenerative rather than a neurodevelopmental process. Gp120 CSF levels exceeded serum gp120 levels in some animals, suggesting local viral protein production in the brain. Further probing of the pathophysiology underlying astrocytic injury in this model is warranted.

Original language	English (US)
Pages (from-to)	116-125
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	292
DOIs	https://doi.org/10.1016/j.jneuroim.2016.01.022
State	Published - Mar 15 2016

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Keywords

Astrocytic loss
HIV-1 transgenic rat
Neuro-HIV
Neuropathology
Neurotoxicity
Viral proteins

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Cite this

Reid, W. C., Ibrahim, W. G., Kim, S. J., Denaro, F., Casas, R., Lee, D. E., Maric, D., & Hammoud, D. A. (2016). Characterization of neuropathology in the HIV-1 transgenic rat at different ages. Journal of Neuroimmunology, 292, 116-125. https://doi.org/10.1016/j.jneuroim.2016.01.022

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AU - Lee, Dianne E.

AU - Maric, Dragan

AU - Hammoud, Dima A.

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10.1016/j.jneuroim.2016.01.022