Characterization of left ventricular cavity flow, wall stress and energy loss by color doppler vector flow mapping in children and adolescents with cardiomyopathy

Mary Craft, Vivek Jani, John Bliamptis, Benjamin T. Barnes, Christopher C. Erickson, Andreas Schuster, David A. Danford, Shelby Kutty

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Vector flow mapping is an emerging echocardiographic method allowing for investigation of intracardiac blood flow mechanics, wall shear stress (WSS), and energy loss (EL). We hypothesized that alterations in EL and WSS will differ among subjects with hypertrophic (HCM), dilated (DCM) cardiomyopathy, and normal controls. Methods: Echocardiograms were prospectively performed with the ProSound F75CV (Hitachi HealthCare., Tokyo, Japan) on all subjects. 2D color Doppler cine loop images were obtained from apical 5 and the apical long axis views and stored digitally. Measurements were averaged over three cardiac cycles using VFM software to derive flow patterns, WSS, and EL. Standard left ventricular (LV) systolic and diastolic functional parameters were also obtained. Results: A total of 85 subjects, 22 with HCM (age 18 ± 9 yrs.), 18 DCM (age 18 ± 9 yrs.), and 45 age and gender matched controls were included in the study. Diastolic wall shear stress was found significantly different in HCM (0.004 ± 0.185 N/m2) compared with DCM (0.397 ± 0.301 N/m2, P < 0.001), and controls (0.175 ± 0.255 N/m2, P = 0.027). Furthermore, indexed systolic EL was found to be significantly elevated in HCM (13.91 ± 13.17 mW/m2/m3) compared with DCM (8.17 ± 9.77 mW/m2/m3, P < 0.001), but not controls (6.45 ± 7.47 mW/m2/m3). Conclusion: Differences in abnormal ventricular mechanics observed in HCM and DCM are reflected in both EL and WSS, and are suggestive that changes in energetic parameters may represent novel indices of ventricular dysfunction.

Original languageEnglish (US)
Article number100703
JournalIJC Heart and Vasculature
Volume32
DOIs
StatePublished - Feb 2021

Keywords

  • Diastolic function
  • Dilated cardiomyopathy
  • Echocardiography
  • Hypertrophic cardiomyopathy
  • Vector flow mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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