Characterization of intraocular pressure increases and management strategies following treatment with fluocinolone acetonide intravitreal implants in the fame trials

Richard K. Parrish, Peter A. Campochiaro, P. Andrew Pearson, Ken Green, Carlo E. Traverso

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVE: To compare elevated intraocular pressure (IOP) management and outcomes among patients with diabetic macular edema who received fluocinolone acetonide (FAc) implants versus sham-control treatment and explore the prior ocular steroid exposure impact on IOP outcomes. PATIENTS AND METHODS: Best-corrected visual acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study charts or electronic VA testers. Goldmann applanation tonometry was used to measure IOP. RESULTS: Elevated IOP was more common in FAcversus sham control-treated patients. Medication, and less often trabeculoplasty or surgery, was used to lower IOP without affecting VA outcomes. No patient treated with 0.2 ?g/day FAc who received prior ocular steroid required IOP-lowering surgery. CONCLUSION: Elevated IOP may occur following FAc implant receipt; however, in the present study, it was manageable and did not impact vision outcomes. Patients previously treated with ocular steroid did not require IOP-lowering surgery following 0.2 ?g/day FAc implant administration.

Original languageEnglish (US)
Pages (from-to)426-435
Number of pages10
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume47
Issue number5
DOIs
StatePublished - May 2016

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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