Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals

Wei Huang, Jonathan Toma, Eric Stawiski, Signe Fransen, Terri Wrin, Neil Parkin, Jeannette M. Whitcomb, Eoin Coakley, Frederick M. Hecht, Steven G. Deeks, Rajesh T. Gandhi, Susan H. Eshleman, Christos J. Petropoulos

Research output: Contribution to journalArticlepeer-review

Abstract

We screened 150 individuals from two recent seroconverter cohorts and found that six (4%) had CXCR4-using viruses. Clonal analysis of these six individuals, along with a seventh individual identified during clinical care as a recent seroconverter, revealed the presence of both X4- and dual-tropic variants in these recently infected adults. The ability of individual CXCR4-using variants to infect cells expressing CD4/CXCR4 or CD4/CCR5 varied dramatically. These data demonstrate that virus populations in some newly infected individuals can consist of either heterogeneous populations containing both CXCR4-using and CCR5-tropic viruses, or homogeneous populations containing only CXCR4-using viruses. The presence of CXCR4-using viruses at early stages of infection suggests that testing for viral tropism before using CCR5 antagonists may be important even in persons with known recent infection. The presence of CXCR4-using viruses in a subset of newly infected individuals could impact the efficacies of vaccine and microbicide strategies that target CCR5-tropic viruses.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalAIDS research and human retroviruses
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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