Characterization of human epigenomes

Zhibin Wang, Dustin E. Schones, Keji Zhao

Research output: Contribution to journalReview article

Abstract

Histone modifications play a key role in regulating transcription and thus ultimately regulate cellular development and differentiation. To understand how histone modifications influence normal development and disease states, a global catalogue of histone modifications and modifying enzymes in normal and disease states is necessary. The first such systematic mapping experiments using the recently developed ChIP-Sequencing technique have revealed a combinatorial modification 'backbone' consisting of multiple histone modifications associated with active transcription. The human epigenomic datasets that are now being produced provide valuable resources for a better understanding of the functional regulatory elements of transcription and the pathways necessary for normal cellular development and pathological conditions.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume19
Issue number2
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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