TY - JOUR
T1 - Characterization of HIV Type 1 Heterosexual Transmission in Yunnan, China
AU - Yu, Xiao Fang
AU - Wang, Xueren
AU - Mao, Penyong
AU - Wang, Shiyi
AU - Li, Zong
AU - Zhang, Jinbing
AU - Garten, Rebecca
AU - Kong, Wei
AU - Lai, Shenghans
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2003/11
Y1 - 2003/11
N2 - The earliest HIV-1 epidemic in China started in Yunnan province, which continues to be one of the most severe areas affected. While HIV-1 infections are spreading rapidly among injection drug users (IDUs) in China, sexual transmission of HIV-1 has also been confirmed, threatening the general population. Recent survey data indicated that heterosexual transmission of HIV-1 in Yunnan was steadily increasing. Diverse HIV-1 strains, including subtype B, C, CRF01, and CRF08, are circulating among individuals who acquired HIV through sexual contacts. Multiple HIV-1 subtypes, including subtypes B, C, and CRF08, were also detected among IDUs. In comparison with other IDU cohorts, intersubject env sequence variation was much higher among IDUs in Yunnan. Growing evidence suggests that unprotected sex continues to occur at high rates among IDUs and their sex partners. Intervention strategies are urgently needed to target individuals at high risk for HIV heterosexual transmission and injection drug use. The complex pattern of HIV-1 distribution in the high-risk populations in Yunnan may have important implications for HIV transmission as well as vaccine development and evaluation.
AB - The earliest HIV-1 epidemic in China started in Yunnan province, which continues to be one of the most severe areas affected. While HIV-1 infections are spreading rapidly among injection drug users (IDUs) in China, sexual transmission of HIV-1 has also been confirmed, threatening the general population. Recent survey data indicated that heterosexual transmission of HIV-1 in Yunnan was steadily increasing. Diverse HIV-1 strains, including subtype B, C, CRF01, and CRF08, are circulating among individuals who acquired HIV through sexual contacts. Multiple HIV-1 subtypes, including subtypes B, C, and CRF08, were also detected among IDUs. In comparison with other IDU cohorts, intersubject env sequence variation was much higher among IDUs in Yunnan. Growing evidence suggests that unprotected sex continues to occur at high rates among IDUs and their sex partners. Intervention strategies are urgently needed to target individuals at high risk for HIV heterosexual transmission and injection drug use. The complex pattern of HIV-1 distribution in the high-risk populations in Yunnan may have important implications for HIV transmission as well as vaccine development and evaluation.
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U2 - 10.1089/088922203322588422
DO - 10.1089/088922203322588422
M3 - Review article
C2 - 14686326
AN - SCOPUS:0345257142
SN - 0889-2229
VL - 19
SP - 1051
EP - 1055
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 11
ER -