Characterization of five nearly full-length genomes of early HIV type 1 strains in Ruili City: Implications for the genesis of CRF07_BC and CRF08_BC circulating in China

Zhaozhu Qiu, Hui Xing, Min Wei, Yijuan Duan, Quanbi Zhao, Jianqing Xu, Yiming Shao

Research output: Contribution to journalArticle

Abstract

To trace the genesis of HIV-1 CRF07_BC and CRF08_BC, two predominant circulating recombinants among intravenous drug users in China, a retrospective molecular epidemiological investigation (1996-1998) was conducted in Ruili city of Yunnan, where the first AIDS epidemic among IDUs was reported in 1989. Fifty-four HIV-1 env C2V3 sequences were determined and genotyped with 49 subtype B and only 5 subtype C strains. The nearly full-length genome analyses of these live env-based subtype C samples revealed that four of them were actually BC recombinants and only one was pure subtype C. The first identified nonrecombinant HIV-1 subtype C, genetically close to Indian C representatives, provided direct evidence for the hypothesis that subtype C in China was introduced from India. Interestingly, three BC recombinants with subtype B as backbones were identified; one BC recombinant that precisely shared a common subtype B segment (nef region) with CRF07_BC and CRF08_BC was described, which indicated a close evolutionary relationship to these two CRFs. The sequences undoubtedly lead us to a better understanding of the emergence of CRF07_BC and CRF08_BC.

Original languageEnglish (US)
Pages (from-to)1051-1056
Number of pages6
JournalAIDS research and human retroviruses
Volume21
Issue number12
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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