Characterization of cytomegalovirus lung infection in non-HIV infected children

Sonia M. Restrepo-Gualteros, Lina E. Jaramillo-Barberi, Monica Gonzalez-Santos, Carlos E. Rodriguez-Martinez, Geovanny F. Perez, Maria J. Gutierrez, Gustavo Nino

Research output: Contribution to journalArticle

Abstract

Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2-4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes.

Original languageEnglish (US)
Pages (from-to)2038-2051
Number of pages14
JournalViruses
Volume6
Issue number5
DOIs
StatePublished - May 7 2014
Externally publishedYes

Keywords

  • CMV
  • Children
  • Ground glass
  • Lung
  • Pneumonia

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Characterization of cytomegalovirus lung infection in non-HIV infected children'. Together they form a unique fingerprint.

  • Cite this

    Restrepo-Gualteros, S. M., Jaramillo-Barberi, L. E., Gonzalez-Santos, M., Rodriguez-Martinez, C. E., Perez, G. F., Gutierrez, M. J., & Nino, G. (2014). Characterization of cytomegalovirus lung infection in non-HIV infected children. Viruses, 6(5), 2038-2051. https://doi.org/10.3390/v6052038