Characterization of cortical spreading depression by imaging of intrinsic optical signals

R. S. Yoon, P. W. Tsang, Frederick Lenz, H. C. Kwan

Research output: Contribution to journalArticle

Abstract

The spatiotemporal progression of cortical spreading depression was investigated by imaging of activity-dependent intrinsic optical signals in rat sensorimotor cortex. In contrast to the traditional conception of a uniformly propagating event, the evolution of the spreading depression was characterized by an asymmetrical propagating wavefront and a non-uniform dispersion of optical signals behind the wavefront. As these optical signals are a reflection of underlying molecular and metabolic processes, the imaging approach to spreading depression might constitute a useful technique for investigating the functional organization as well the pathophysiology of the cerebral cortex.

Original languageEnglish (US)
Pages (from-to)2671-2674
Number of pages4
JournalNeuroReport
Volume7
Issue number15-17
StatePublished - 1996

Fingerprint

Cortical Spreading Depression
Optical Imaging
Cerebral Cortex
Sensorimotor Cortex

Keywords

  • Cerebral cortex
  • Imaging
  • Intrinsic optical signals
  • Rat
  • Spreading depression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yoon, R. S., Tsang, P. W., Lenz, F., & Kwan, H. C. (1996). Characterization of cortical spreading depression by imaging of intrinsic optical signals. NeuroReport, 7(15-17), 2671-2674.

Characterization of cortical spreading depression by imaging of intrinsic optical signals. / Yoon, R. S.; Tsang, P. W.; Lenz, Frederick; Kwan, H. C.

In: NeuroReport, Vol. 7, No. 15-17, 1996, p. 2671-2674.

Research output: Contribution to journalArticle

Yoon, RS, Tsang, PW, Lenz, F & Kwan, HC 1996, 'Characterization of cortical spreading depression by imaging of intrinsic optical signals', NeuroReport, vol. 7, no. 15-17, pp. 2671-2674.
Yoon, R. S. ; Tsang, P. W. ; Lenz, Frederick ; Kwan, H. C. / Characterization of cortical spreading depression by imaging of intrinsic optical signals. In: NeuroReport. 1996 ; Vol. 7, No. 15-17. pp. 2671-2674.
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