Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET

Jonathan M. DuBois, Olivier Rousset, Jared Rowley, Manuel Porras-Betancourt, Andrew J. Reader, Aurelie Labbe, Gassan Massarweh, Jean Paul Soucy, Pedro Rosa-Neto, Eliane Kobayashi

Research output: Contribution to journalArticle

Abstract

Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.

Original languageEnglish (US)
Pages (from-to)152-162
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Keywords

  • Healthy controls
  • Metabotropic glutamate receptor 5
  • Positron emission tomography
  • [C]ABP688

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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