Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET

Jonathan M. DuBois; Olivier G. Rousset; Jared Rowley; Manuel Porras-Betancourt; Andrew J. Reader; Aurelie Labbe; Gassan Massarweh; Jean Paul Soucy; Pedro Rosa-Neto; Eliane Kobayashi

doi:10.1007/s00259-015-3167-6

Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [¹¹C]ABP688 PET

Jonathan M. DuBois, Olivier G. Rousset, Jared Rowley, Manuel Porras-Betancourt, Andrew J. Reader, Aurelie Labbe, Gassan Massarweh, Jean Paul Soucy, Pedro Rosa-Neto, Eliane Kobayashi

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [¹¹C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [¹¹C]ABP688 binding potential (BP_ND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [¹¹C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BP_ND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [¹¹C]ABP688 BP_ND in the lateral prefrontal and anterior cingulate cortices. The lowest [¹¹C]ABP688 BP_ND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [¹¹C]ABP688 BP_ND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.

Original language	English (US)
Pages (from-to)	152-162
Number of pages	11
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	43
Issue number	1
DOIs	https://doi.org/10.1007/s00259-015-3167-6
State	Published - Jan 1 2016

Keywords

Healthy controls
Metabotropic glutamate receptor 5
Positron emission tomography
[C]ABP688

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s00259-015-3167-6

Cite this

DuBois, J. M., Rousset, O. G., Rowley, J., Porras-Betancourt, M., Reader, A. J., Labbe, A., Massarweh, G., Soucy, J. P., Rosa-Neto, P., & Kobayashi, E. (2016). Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [¹¹C]ABP688 PET. European Journal of Nuclear Medicine and Molecular Imaging, 43(1), 152-162. https://doi.org/10.1007/s00259-015-3167-6

Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [¹¹C]ABP688 PET. / DuBois, Jonathan M.; Rousset, Olivier G.; Rowley, Jared; Porras-Betancourt, Manuel; Reader, Andrew J.; Labbe, Aurelie; Massarweh, Gassan; Soucy, Jean Paul; Rosa-Neto, Pedro; Kobayashi, Eliane.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, No. 1, 01.01.2016, p. 152-162.

Research output: Contribution to journal › Article › peer-review

DuBois, JM, Rousset, OG, Rowley, J, Porras-Betancourt, M, Reader, AJ, Labbe, A, Massarweh, G, Soucy, JP, Rosa-Neto, P & Kobayashi, E 2016, 'Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [¹¹C]ABP688 PET', European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 1, pp. 152-162. https://doi.org/10.1007/s00259-015-3167-6

DuBois, Jonathan M. ; Rousset, Olivier G. ; Rowley, Jared ; Porras-Betancourt, Manuel ; Reader, Andrew J. ; Labbe, Aurelie ; Massarweh, Gassan ; Soucy, Jean Paul ; Rosa-Neto, Pedro ; Kobayashi, Eliane. / Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [¹¹C]ABP688 PET. In: European Journal of Nuclear Medicine and Molecular Imaging. 2016 ; Vol. 43, No. 1. pp. 152-162.

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title = "Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET",

abstract = "Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.",

keywords = "Healthy controls, Metabotropic glutamate receptor 5, Positron emission tomography, [C]ABP688",

author = "DuBois, {Jonathan M.} and Rousset, {Olivier G.} and Jared Rowley and Manuel Porras-Betancourt and Reader, {Andrew J.} and Aurelie Labbe and Gassan Massarweh and Soucy, {Jean Paul} and Pedro Rosa-Neto and Eliane Kobayashi",

note = "Funding Information: The study was funded by the Savoy Foundation for Epilepsy ( www.savoy-foundation.ca ) (pilot project grant to EK and PRN and PhD studentship to JMD), and partially by the American Epilepsy Society ( www.aesnet.org ) (Early Career Physician Scientist Award to EK), Canadian Institutes of Health Research (CIHR) ( www.cihr-irsc.gc.ca ) [MOP-115131 to PRN and MOP-93614 to EK], and the Fonds de la recherche en sant{\'e} du Qu{\'e}bec ( www.frqs.gouv.qc.ca ) (PRN, research fellow). Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",

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doi = "10.1007/s00259-015-3167-6",

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T1 - Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET

AU - DuBois, Jonathan M.

AU - Rousset, Olivier G.

AU - Rowley, Jared

AU - Porras-Betancourt, Manuel

AU - Reader, Andrew J.

AU - Labbe, Aurelie

AU - Massarweh, Gassan

AU - Soucy, Jean Paul

AU - Rosa-Neto, Pedro

AU - Kobayashi, Eliane

N1 - Funding Information: The study was funded by the Savoy Foundation for Epilepsy ( www.savoy-foundation.ca ) (pilot project grant to EK and PRN and PhD studentship to JMD), and partially by the American Epilepsy Society ( www.aesnet.org ) (Early Career Physician Scientist Award to EK), Canadian Institutes of Health Research (CIHR) ( www.cihr-irsc.gc.ca ) [MOP-115131 to PRN and MOP-93614 to EK], and the Fonds de la recherche en santé du Québec ( www.frqs.gouv.qc.ca ) (PRN, research fellow). Publisher Copyright: © 2015, Springer-Verlag Berlin Heidelberg.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.

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KW - Healthy controls

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KW - [C]ABP688

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