Abstract
Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-162 |
| Number of pages | 11 |
| Journal | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Healthy controls
- Metabotropic glutamate receptor 5
- Positron emission tomography
- [C]ABP688
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET. / DuBois, Jonathan M.; Rousset, Olivier; Rowley, Jared; Porras-Betancourt, Manuel; Reader, Andrew J.; Labbe, Aurelie; Massarweh, Gassan; Soucy, Jean Paul; Rosa-Neto, Pedro; Kobayashi, Eliane.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, No. 1, 01.01.2016, p. 152-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [11C]ABP688 PET
AU - DuBois, Jonathan M.
AU - Rousset, Olivier
AU - Rowley, Jared
AU - Porras-Betancourt, Manuel
AU - Reader, Andrew J.
AU - Labbe, Aurelie
AU - Massarweh, Gassan
AU - Soucy, Jean Paul
AU - Rosa-Neto, Pedro
AU - Kobayashi, Eliane
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.
AB - Purpose: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [11C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [11C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals. Methods: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [11C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere. Results: We found the highest [11C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [11C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [11C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction. Conclusions: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.
KW - Healthy controls
KW - Metabotropic glutamate receptor 5
KW - Positron emission tomography
KW - [C]ABP688
UR - http://www.scopus.com/inward/record.url?scp=84951908961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951908961&partnerID=8YFLogxK
U2 - 10.1007/s00259-015-3167-6
DO - 10.1007/s00259-015-3167-6
M3 - Article
C2 - 26290423
AN - SCOPUS:84951908961
VL - 43
SP - 152
EP - 162
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 1
ER -