Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI

Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh-Ardalan, Alejandro F. Frangi, Christos Davatzikos, Hamidreza Saligheh Rad

Research output: Contribution to journalArticle

Abstract

Background: Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity. Purpose: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. Study Type: Prospective. Population: Fifty-one tissue specimens were collected using image-guided localized biopsy surgery from 10 patients with newly diagnosed gliomas. Field Strength/Sequence: Conventional and quantitative MR images consisting of pre- and postcontrast T1w, T2w, T2-FLAIR, T2-relaxometry, DWI, DTI, IVIM, and DSC-MRI were acquired preoperatively at 3T. Assessment: Biopsy specimens were histopathologically attributed to glioma tissue subregion categories of active tumor (AT), infiltrative edema (IE), and normal tissue (NT) subregions. For each tissue sample, a feature vector comprising 15 MRI-based parameters was derived from preoperative images and assessed by a machine learning algorithm to determine the best multiparametric feature combination for characterizing the tissue subregions. Statistical Tests: For discrimination of AT, IE, and NT subregions, a one-way analysis of variance (ANOVA) test and for pairwise tissue subregion differentiation, Tukey honest significant difference, and Games-Howell tests were applied (P<0.05). Cross-validated feature selection and classification methods were implemented for identification of accurate multiparametric MRI parameter combination. Results: After exclusion of 17 tissue specimens, 34 samples (AT=6, IE=20, and NT=8) were considered for analysis. Highest accuracies and statistically significant differences for discrimination of IE from NT and AT from NT were observed for diffusion-based parameters (AUCs >90%), and the perfusion-derived parameter as the most accurate feature in distinguishing IE from AT. A combination of "CBV, MD, T2_ISO, FLAIR" parameters showed high diagnostic performance for identification of the three subregions (AUC ∼90%). Data Conclusion: Integration of a few quantitative along with conventional MRI parameters may provide a potential multiparametric imaging biomarker for predicting the histopathologically proven glioma tissue subregions.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Glioma
  • Imaging biomarker
  • Intratumor heterogeneity
  • Machine learning
  • Multiparametric MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Fathi Kazerooni, A., Nabil, M., Zeinali Zadeh, M., Firouznia, K., Azmoudeh-Ardalan, F., Frangi, A. F., Davatzikos, C., & Saligheh Rad, H. (Accepted/In press). Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.25963