Characterization of a trichophyton mentagrophytes and its diffusible pigment

W. G. Merz, K. O. Lloyd, Margarita Silva-Hutner

Research output: Contribution to journalArticle

Abstract

A clinical isolate of Trichophyton mentagrophytes which produces a diffusible red-brown pigment as well as typical microconidia en grappe and abundant spirals on Sabouraud's Dextrose Agar has been studied. It splits urea and perforates hair in vitro but does not produce pigment on cornmeal agar or require vitamins for growth. A low molecular weight, red pigment, partially purified from culture filtrates by gel-filtration, was characterized as 2-carboxy 2,3-dihydroindole-5,6-quinone, an intermediate in melanin biosynthesis. It is water soluble, lacks free amino groups, unstable in alkaline buffers, and has spectral absorption peaks at 320-340 nm and 450-490 nm.

Original languageEnglish (US)
Pages (from-to)86-93
Number of pages8
JournalMedical mycology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Infectious Diseases

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