A total of 82 human immunodeficiency virus (HIV)-l-specific cytolytic T lymphocyte (CTL) clones were isolated and characterized from 5 HIV-infected subjects, utilizing multiple HLA class I alleles. B62-restricted. HIV-1 gag- specific CTL clones isolated from a single blood sample from I subject used four different Vβ gene rearrangements. Multiple CTL clones could be isolated from the same time point directed against HIV-1 gag, nef, and env from 1 subject. A prospective analysis resulted in the isolation of CTL clones from 1 subject directed against multiple HIV-1 antigens, including the same highly conserved nef peptide, over a 1-year period, in the absence of detectable circulating viral plasma RNA. These data suggest that in some persons without clinical progression and low levels of circulating HIV-1, the CTL response is polyclonal, is directed against multiple HIV-1 proteins, including highly conserved peptides within these proteins, and is maintained over time.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Infectious Diseases|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health