Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression

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Abstract

A total of 82 human immunodeficiency virus (HIV)-l-specific cytolytic T lymphocyte (CTL) clones were isolated and characterized from 5 HIV-infected subjects, utilizing multiple HLA class I alleles. B62-restricted. HIV-1 gag- specific CTL clones isolated from a single blood sample from I subject used four different Vβ gene rearrangements. Multiple CTL clones could be isolated from the same time point directed against HIV-1 gag, nef, and env from 1 subject. A prospective analysis resulted in the isolation of CTL clones from 1 subject directed against multiple HIV-1 antigens, including the same highly conserved nef peptide, over a 1-year period, in the absence of detectable circulating viral plasma RNA. These data suggest that in some persons without clinical progression and low levels of circulating HIV-1, the CTL response is polyclonal, is directed against multiple HIV-1 proteins, including highly conserved peptides within these proteins, and is maintained over time.

Original languageEnglish (US)
Pages (from-to)1360-1367
Number of pages8
JournalJournal of Infectious Diseases
Volume175
Issue number6
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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