Characterization of a novel P[25],G11 human group A rotavirus

Mustafizur Rahman; Jelle Matthijnssens; Sharifun Nahar; Goutam Podder; David A. Sack; Tasnim Azim; Marc Van Ranst

doi:10.1128/JCM.43.7.3208-3212.2005

Characterization of a novel P[25],G11 human group A rotavirus

Mustafizur Rahman, Jelle Matthijnssens, Sharifun Nahar, Goutam Podder, David A. Sack, Tasnim Azim, Marc Van Ranst

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].

Original language	English (US)
Pages (from-to)	3208-3212
Number of pages	5
Journal	Journal of clinical microbiology
Volume	43
Issue number	7
DOIs	https://doi.org/10.1128/JCM.43.7.3208-3212.2005
State	Published - Jul 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.43.7.3208-3212.2005

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title = "Characterization of a novel P[25],G11 human group A rotavirus",

abstract = "A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].",

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AU - Rahman, Mustafizur

AU - Matthijnssens, Jelle

AU - Nahar, Sharifun

AU - Podder, Goutam

AU - Sack, David A.

AU - Azim, Tasnim

AU - Van Ranst, Marc

PY - 2005/7

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AB - A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].

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Characterization of a novel P[25],G11 human group A rotavirus

Abstract

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