Characterization of a novel P[25],G11 human group A rotavirus

Mustafizur Rahman, Jelle Matthijnssens, Sharifun Nahar, Goutam Podder, David A. Sack, Tasnim Azim, Marc Van Ranst

Research output: Contribution to journalArticlepeer-review

Abstract

A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].

Original languageEnglish (US)
Pages (from-to)3208-3212
Number of pages5
JournalJournal of clinical microbiology
Volume43
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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