Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin

Marcy Peteroy, Anatoly Severin, Frances Zhao, Dalya Rosner, Uri Lopatin, Hataichanouk Scherman, Aimee Belanger, Bohdan Harvey, Graham F. Hatfull, Patrick J. Brennan, Nancy D. Connell

Research output: Contribution to journalArticlepeer-review

Abstract

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

Original languageEnglish (US)
Pages (from-to)1701-1704
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin'. Together they form a unique fingerprint.

Cite this