Characterization of a candidate locus for malaria susceptibility in human populations: A (TA)n microsatellite in the promoter region of the CYBB gene, the gp91phox subunit of the NADPH oxidase

G. B. Soares-Souza, E. Tarazona-Santos, S. J. Chanock

Research output: Contribution to journalArticlepeer-review

Abstract

We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA) n microsatellite should be directly tested in genetic epidemiology studies.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalInternational Journal of Immunogenetics
Volume35
Issue number2
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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