Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy

Richard L. Blackmon, Thomas C. Hutchens, Luke A. Hardy, Pierce B. Irby, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our laboratory is currently studying the Thulium fiber laser (TFL) as a potential alternative laser lithotripter to the standard clinical Holmium:YAG laser. We have previously demonstrated efficient coupling of TFL energy into fibers as small as 100-μm-core-diameter without damage to the proximal end. Although smaller fibers have greater tendency to degrade at the distal tip during lithotripsy, fiber diameters (≤ 200 μm) have been shown to increase saline irrigation rates through the working channel of a flexible ureteroscope, maximize ureteroscope deflection, and reduce stone retropulsion during laser lithotripsy. In this study, a 50-μm-core-diameter, 85-μm-outer-diameter fiber is characterized for TFL ablation of human calcium oxalate monohydrate urinary stones, ex vivo. The stone ablation rate was measured to be 70 ± 22 μg/s for 35-mJ-pulse-energy, 500-μs-pulse-duration, and 50-Hz-pulse-rate. The ureteroscope working channel flow rate including the 50-μm fiber decreased by only 10% with no impairment of ureteroscope deflection. The fiber delivered up to 15.4 ± 5.9 W under extreme bending (5-mm-radius) conditions. Stone retropulsion and fiber burn-back averaged 201 ± 336 and 3000 ± 2600 μm, respectively, after 2 minutes. With further development, Thulium fiber laser lithotripsy using ultra-small, 50-μm-core fibers may introduce new integration and miniaturization possibilities and potentially provide an alternatiμe to conventional Holmium:YAG laser lithotripsy using larger fibers.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8926
ISBN (Print)9780819498397
DOIs
StatePublished - 2014
EventPhotonic Therapeutics and Diagnostics X - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Other

OtherPhotonic Therapeutics and Diagnostics X
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Fingerprint

Thulium
Laser Lithotripsy
Ureteroscopes
Optical Fibers
thulium
Fiber lasers
fiber lasers
Optical fibers
optical fibers
Lasers
fibers
Fibers
Solid-State Lasers
Holmium
Miniaturization
rocks
Calcium Oxalate
Urinary Calculi
Lithotripsy
Laser Therapy

Keywords

  • 50-μm-core fiber
  • Ablation
  • Burnback
  • Lithotripsy
  • Retropulsion
  • Thulium
  • Urinary stones

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Blackmon, R. L., Hutchens, T. C., Hardy, L. A., Irby, P. B., & Fried, N. M. (2014). Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8926). [89261F] SPIE. https://doi.org/10.1117/12.2035556

Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy. / Blackmon, Richard L.; Hutchens, Thomas C.; Hardy, Luke A.; Irby, Pierce B.; Fried, Nathaniel M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926 SPIE, 2014. 89261F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blackmon, RL, Hutchens, TC, Hardy, LA, Irby, PB & Fried, NM 2014, Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8926, 89261F, SPIE, Photonic Therapeutics and Diagnostics X, San Francisco, CA, United States, 2/1/14. https://doi.org/10.1117/12.2035556
Blackmon RL, Hutchens TC, Hardy LA, Irby PB, Fried NM. Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926. SPIE. 2014. 89261F https://doi.org/10.1117/12.2035556
Blackmon, Richard L. ; Hutchens, Thomas C. ; Hardy, Luke A. ; Irby, Pierce B. ; Fried, Nathaniel M. / Characterization of a 50-μm-core optical fiber for potential use in Thulium fiber laser lithotripsy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926 SPIE, 2014.
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abstract = "Our laboratory is currently studying the Thulium fiber laser (TFL) as a potential alternative laser lithotripter to the standard clinical Holmium:YAG laser. We have previously demonstrated efficient coupling of TFL energy into fibers as small as 100-μm-core-diameter without damage to the proximal end. Although smaller fibers have greater tendency to degrade at the distal tip during lithotripsy, fiber diameters (≤ 200 μm) have been shown to increase saline irrigation rates through the working channel of a flexible ureteroscope, maximize ureteroscope deflection, and reduce stone retropulsion during laser lithotripsy. In this study, a 50-μm-core-diameter, 85-μm-outer-diameter fiber is characterized for TFL ablation of human calcium oxalate monohydrate urinary stones, ex vivo. The stone ablation rate was measured to be 70 ± 22 μg/s for 35-mJ-pulse-energy, 500-μs-pulse-duration, and 50-Hz-pulse-rate. The ureteroscope working channel flow rate including the 50-μm fiber decreased by only 10{\%} with no impairment of ureteroscope deflection. The fiber delivered up to 15.4 ± 5.9 W under extreme bending (5-mm-radius) conditions. Stone retropulsion and fiber burn-back averaged 201 ± 336 and 3000 ± 2600 μm, respectively, after 2 minutes. With further development, Thulium fiber laser lithotripsy using ultra-small, 50-μm-core fibers may introduce new integration and miniaturization possibilities and potentially provide an alternatiμe to conventional Holmium:YAG laser lithotripsy using larger fibers.",
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