Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial

Mihai Gheorghiade; Joseph S. Rossi; William Cotts; David D. Shin; Anne S. Hellkamp; Ileana L. Piña; Gregg C. Fonarow; Teresa DeMarco; Daniel F. Pauly; Joseph Rogers; Thomas G. DiSalvo; Javed Butler; Joshua M. Hare; Gary S. Francis; Wendy Gattis Stough; Christopher M. O'Connor

doi:10.1001/archinte.167.18.1998

Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial

Mihai Gheorghiade, Joseph S. Rossi, William Cotts, David D. Shin, Anne S. Hellkamp, Ileana L. Piña, Gregg C. Fonarow, Teresa DeMarco, Daniel F. Pauly, Joseph Rogers, Thomas G. DiSalvo, Javed Butler, Joshua M. Hare, Gary S. Francis, Wendy Gattis Stough, Christopher M. O'Connor

School of Medicine

Research output: Contribution to journal › Article › peer-review

250 Scopus citations

Abstract

Background: Mild hyponatremia is relatively common in patients hospitalized with heart failure (HF). To our knowledge, the association of hyponatremia with outcomes has not been evaluated in the context of in-hospital clinical course including central hemodynamics and changes in serum sodium level. Methods: The ESCAPE trial (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) was a randomized, controlled study designed to evaluate the utility of a pulmonary artery catheter plus clinical assessment vs clinical assessment alone in guiding therapy in patients hospitalized with New York Heart Association class IV HF due to systolic dysfunction (left ventricular ejection fraction

Original language	English (US)
Pages (from-to)	1998-2005
Number of pages	8
Journal	Archives of Internal Medicine
Volume	167
Issue number	18
DOIs	https://doi.org/10.1001/archinte.167.18.1998
State	Published - Oct 8 2007

ASJC Scopus subject areas

Internal Medicine

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10.1001/archinte.167.18.1998

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Gheorghiade, M., Rossi, J. S., Cotts, W., Shin, D. D., Hellkamp, A. S., Piña, I. L., Fonarow, G. C., DeMarco, T., Pauly, D. F., Rogers, J., DiSalvo, T. G., Butler, J., Hare, J. M., Francis, G. S., Stough, W. G., & O'Connor, C. M. (2007). Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial. Archives of Internal Medicine, 167(18), 1998-2005. https://doi.org/10.1001/archinte.167.18.1998

Gheorghiade, M, Rossi, JS, Cotts, W, Shin, DD, Hellkamp, AS, Piña, IL, Fonarow, GC, DeMarco, T, Pauly, DF, Rogers, J, DiSalvo, TG, Butler, J, Hare, JM, Francis, GS, Stough, WG & O'Connor, CM 2007, 'Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial', Archives of Internal Medicine, vol. 167, no. 18, pp. 1998-2005. https://doi.org/10.1001/archinte.167.18.1998

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abstract = "Background: Mild hyponatremia is relatively common in patients hospitalized with heart failure (HF). To our knowledge, the association of hyponatremia with outcomes has not been evaluated in the context of in-hospital clinical course including central hemodynamics and changes in serum sodium level. Methods: The ESCAPE trial (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) was a randomized, controlled study designed to evaluate the utility of a pulmonary artery catheter plus clinical assessment vs clinical assessment alone in guiding therapy in patients hospitalized with New York Heart Association class IV HF due to systolic dysfunction (left ventricular ejection fraction ",

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AU - Shin, David D.

AU - Hellkamp, Anne S.

AU - Piña, Ileana L.

AU - Fonarow, Gregg C.

AU - DeMarco, Teresa

AU - Pauly, Daniel F.

AU - Rogers, Joseph

AU - DiSalvo, Thomas G.

AU - Butler, Javed

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AU - O'Connor, Christopher M.

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Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial

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