TY - JOUR
T1 - Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort
AU - the ONDRI Investigators
AU - Sunderland, Kelly M.
AU - Beaton, Derek
AU - Arnott, Stephen R.
AU - Kleinstiver, Peter
AU - Kwan, Donna
AU - Lawrence-Dewar, Jane M.
AU - Ramirez, Joel
AU - Tan, Brian
AU - Bartha, Robert
AU - Black, Sandra E.
AU - Borrie, Michael
AU - Brien, Donald
AU - Casaubon, Leanne K.
AU - Coe, Brian C.
AU - Cornish, Benjamin
AU - Dilliott, Allison A.
AU - Dowlatshahi, Dar
AU - Finger, Elizabeth
AU - Fischer, Corinne
AU - Frank, Andrew
AU - Fraser, Julia
AU - Freedman, Morris
AU - Greenberg, Barry
AU - Grimes, David A.
AU - Hassan, Ayman
AU - Hatch, Wendy
AU - Hegele, Robert A.
AU - Hudson, Christopher
AU - Jog, Mandar
AU - Kumar, Sanjeev
AU - Lang, Anthony
AU - Levine, Brian
AU - Lou, Wendy
AU - Mandzia, Jennifer
AU - Marras, Connie
AU - McIlroy, William
AU - Montero-Odasso, Manuel
AU - Munoz, David G.
AU - Munoz, Douglas P.
AU - Orange, Joseph B.
AU - Park, David S.
AU - Pasternak, Stephen H.
AU - Pieruccini-Faria, Frederico
AU - Rajji, Tarek K.
AU - Roberts, Angela C.
AU - Robinson, John F.
AU - Rogaeva, Ekaterina
AU - Sahlas, Demetrios J.
AU - Saposnik, Gustavo
AU - Scott, Christopher J.M.
N1 - Publisher Copyright:
© 2022 the Alzheimer's Association.
PY - 2023/1
Y1 - 2023/1
N2 - Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods: This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results: We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion: Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.
AB - Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods: This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results: We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion: Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.
KW - Alzheimer's disease
KW - Parkinson's disease
KW - amnestic mild cognitive impairment
KW - amyotrophic lateral sclerosis
KW - cerebrovascular disease
KW - cohort study
KW - dementia
KW - frontotemporal dementia spectrum disorder
KW - neurodegenerative disease
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UR - http://www.scopus.com/inward/citedby.url?scp=85133238338&partnerID=8YFLogxK
U2 - 10.1002/alz.12632
DO - 10.1002/alz.12632
M3 - Article
C2 - 36318754
AN - SCOPUS:85133238338
SN - 1552-5260
VL - 19
SP - 226
EP - 243
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 1
ER -