Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis

Research output: Contribution to journalArticle

Abstract

Background and objectives: The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN). Design, setting, participants, & measurements: Pathology reports were reviewed for patients who had HIV infection and underwent renal biopsy at Johns Hopkins Hospital from January 1, 1995, through January 1, 2008. Patients who received a diagnosis of AIN without evidence of HIV-associated nephropathy were identified, and their clinical course was reviewed up to 18 months after biopsy. Results: Of 262 biopsies, 29 (11%) patients who had AIN without evidence of HIV-associated nephropathy were identified. The mean age at the time of biopsy was 47.5 years (range 28 to 71 years), 17 (59%) were men, and 23 (79%) were black. The majority (62%) of patients were on antiretroviral therapy, 59% were current or former intravenous drug users, and 62% had hepatitis C co-infection. Drugs were identified as the cause of AIN in the majority (72%) of cases. Nonsteroidal antiinflammatory drugs were most commonly implicated, followed by sulfamethoxazole/trimethoprim. Antiretroviral therapy was identified as the cause in only three cases. None of the patients presented with the classic triad of fever, rash, and pyuria, and only seven (24%) patients presented with

Original languageEnglish (US)
Pages (from-to)798-804
Number of pages7
JournalClinical Journal of the American Society of Nephrology
Volume5
Issue number5
DOIs
StatePublished - May 1 2010

Fingerprint

Interstitial Nephritis
HIV
Biopsy
AIDS-Associated Nephropathy
HIV Infections
Pyuria
Sulfamethoxazole Drug Combination Trimethoprim
Hepatitis C
Drug Users
Exanthema
Coinfection
Pharmaceutical Preparations
Anti-Inflammatory Agents
Fever
Pathology
Kidney
Therapeutics

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

@article{24128613ad22421fb28bf363f04f6856,
title = "Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis",
abstract = "Background and objectives: The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN). Design, setting, participants, & measurements: Pathology reports were reviewed for patients who had HIV infection and underwent renal biopsy at Johns Hopkins Hospital from January 1, 1995, through January 1, 2008. Patients who received a diagnosis of AIN without evidence of HIV-associated nephropathy were identified, and their clinical course was reviewed up to 18 months after biopsy. Results: Of 262 biopsies, 29 (11{\%}) patients who had AIN without evidence of HIV-associated nephropathy were identified. The mean age at the time of biopsy was 47.5 years (range 28 to 71 years), 17 (59{\%}) were men, and 23 (79{\%}) were black. The majority (62{\%}) of patients were on antiretroviral therapy, 59{\%} were current or former intravenous drug users, and 62{\%} had hepatitis C co-infection. Drugs were identified as the cause of AIN in the majority (72{\%}) of cases. Nonsteroidal antiinflammatory drugs were most commonly implicated, followed by sulfamethoxazole/trimethoprim. Antiretroviral therapy was identified as the cause in only three cases. None of the patients presented with the classic triad of fever, rash, and pyuria, and only seven (24{\%}) patients presented with",
author = "Parkhie, {Shyam M.} and Fine, {Derek M} and Lucas, {Gregory M} and Mohamed Atta",
year = "2010",
month = "5",
day = "1",
doi = "10.2215/CJN.08211109",
language = "English (US)",
volume = "5",
pages = "798--804",
journal = "Clinical journal of the American Society of Nephrology : CJASN",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "5",

}

TY - JOUR

T1 - Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis

AU - Parkhie, Shyam M.

AU - Fine, Derek M

AU - Lucas, Gregory M

AU - Atta, Mohamed

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background and objectives: The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN). Design, setting, participants, & measurements: Pathology reports were reviewed for patients who had HIV infection and underwent renal biopsy at Johns Hopkins Hospital from January 1, 1995, through January 1, 2008. Patients who received a diagnosis of AIN without evidence of HIV-associated nephropathy were identified, and their clinical course was reviewed up to 18 months after biopsy. Results: Of 262 biopsies, 29 (11%) patients who had AIN without evidence of HIV-associated nephropathy were identified. The mean age at the time of biopsy was 47.5 years (range 28 to 71 years), 17 (59%) were men, and 23 (79%) were black. The majority (62%) of patients were on antiretroviral therapy, 59% were current or former intravenous drug users, and 62% had hepatitis C co-infection. Drugs were identified as the cause of AIN in the majority (72%) of cases. Nonsteroidal antiinflammatory drugs were most commonly implicated, followed by sulfamethoxazole/trimethoprim. Antiretroviral therapy was identified as the cause in only three cases. None of the patients presented with the classic triad of fever, rash, and pyuria, and only seven (24%) patients presented with

AB - Background and objectives: The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN). Design, setting, participants, & measurements: Pathology reports were reviewed for patients who had HIV infection and underwent renal biopsy at Johns Hopkins Hospital from January 1, 1995, through January 1, 2008. Patients who received a diagnosis of AIN without evidence of HIV-associated nephropathy were identified, and their clinical course was reviewed up to 18 months after biopsy. Results: Of 262 biopsies, 29 (11%) patients who had AIN without evidence of HIV-associated nephropathy were identified. The mean age at the time of biopsy was 47.5 years (range 28 to 71 years), 17 (59%) were men, and 23 (79%) were black. The majority (62%) of patients were on antiretroviral therapy, 59% were current or former intravenous drug users, and 62% had hepatitis C co-infection. Drugs were identified as the cause of AIN in the majority (72%) of cases. Nonsteroidal antiinflammatory drugs were most commonly implicated, followed by sulfamethoxazole/trimethoprim. Antiretroviral therapy was identified as the cause in only three cases. None of the patients presented with the classic triad of fever, rash, and pyuria, and only seven (24%) patients presented with

UR - http://www.scopus.com/inward/record.url?scp=77952304683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952304683&partnerID=8YFLogxK

U2 - 10.2215/CJN.08211109

DO - 10.2215/CJN.08211109

M3 - Article

C2 - 20338962

AN - SCOPUS:77952304683

VL - 5

SP - 798

EP - 804

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 5

ER -