TY - JOUR
T1 - Characteristics of Patients With Antiphospholipid Antibody Positivity in the APS ACTION International Clinical Database and Repository
AU - APS ACTION Investigators
AU - Sevim, Ecem
AU - Zisa, Diane
AU - Andrade, Danieli
AU - Sciascia, Savino
AU - Pengo, Vittorio
AU - Tektonidou, Maria G.
AU - Ugarte, Amaia
AU - Gerosa, Maria
AU - Belmont, H. Michael
AU - Zamorano, Maria Angeles Aguirre
AU - Fortin, Paul R.
AU - Ji, Lanlan
AU - Efthymiou, Maria
AU - Cohen, Hannah
AU - Branch, D. Ware
AU - de Jesus, Guilherme Ramires
AU - Andreoli, Laura
AU - Petri, Michelle
AU - Rodriguez, Esther
AU - Cervera, Ricard
AU - Knight, Jason S.
AU - Atsumi, Tatsuya
AU - Willis, Rohan
AU - Roubey, Robert
AU - Bertolaccini, Maria Laura
AU - Erkan, Doruk
AU - Barbhaiya, Medha
N1 - Publisher Copyright:
© 2020, American College of Rheumatology
PY - 2022/2
Y1 - 2022/2
N2 - Objective: To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (APS) Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository, overall and by clinical and laboratory subtypes. Methods: The APS ACTION registry includes adults who persistently had positivity for aPLs. We evaluated baseline sociodemographic and aPL-related (APS classification criteria and “non-criteria”) characteristics of patients overall and in subgroups (aPL-positive without APS, APS overall, thrombotic APS only, obstetric APS only, and both thrombotic APS/obstetric APS). We assessed baseline characteristics of patients tested for the presence of three aPLs (lupus anticoagulant [LAC] test, anticardiolipin antibody [aCL], and anti–β2-glycoprotein I [anti-β2GPI]) antibodies by aPL profiles (LAC only, single, double, and triple aPL positivity). Results: The 804 aPL-positive patients assessed in the present study had a mean age of 45 ± 13 years, were 74% female, and 68% White; additionally, 36% had other systemic autoimmune diseases. Of these 804 aPL-positive patients, 80% were classified as having APS (with 55% having thrombotic APS, 9% obstetric APS, and 15% thrombotic APS/obstetric APS). In the overall cohort, 71% had vascular thrombosis, 50% with a history of pregnancy had obstetric morbidity, and 56% had experienced at least one non-criteria manifestation. Among those with three aPLs tested (n = 660), 42% were triple aPL–positive. While single–, double–, and triple aPL–positive subgroups had similar frequencies of vascular, obstetric, and non-criteria events, these events were lowest in the single aPL subgroup, which consisted of aCLs or anti-β2GPI only. Conclusion: Our study demonstrates the heterogeneity of aPL-related clinical manifestations and laboratory profiles in a multicenter international cohort. Within single aPL positivity, LAC may be a major contributor to clinical events. Future prospective analyses, using standardized core laboratory aPL tests, will help clarify aPL risk profiles and improve risk stratification.
AB - Objective: To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (APS) Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository, overall and by clinical and laboratory subtypes. Methods: The APS ACTION registry includes adults who persistently had positivity for aPLs. We evaluated baseline sociodemographic and aPL-related (APS classification criteria and “non-criteria”) characteristics of patients overall and in subgroups (aPL-positive without APS, APS overall, thrombotic APS only, obstetric APS only, and both thrombotic APS/obstetric APS). We assessed baseline characteristics of patients tested for the presence of three aPLs (lupus anticoagulant [LAC] test, anticardiolipin antibody [aCL], and anti–β2-glycoprotein I [anti-β2GPI]) antibodies by aPL profiles (LAC only, single, double, and triple aPL positivity). Results: The 804 aPL-positive patients assessed in the present study had a mean age of 45 ± 13 years, were 74% female, and 68% White; additionally, 36% had other systemic autoimmune diseases. Of these 804 aPL-positive patients, 80% were classified as having APS (with 55% having thrombotic APS, 9% obstetric APS, and 15% thrombotic APS/obstetric APS). In the overall cohort, 71% had vascular thrombosis, 50% with a history of pregnancy had obstetric morbidity, and 56% had experienced at least one non-criteria manifestation. Among those with three aPLs tested (n = 660), 42% were triple aPL–positive. While single–, double–, and triple aPL–positive subgroups had similar frequencies of vascular, obstetric, and non-criteria events, these events were lowest in the single aPL subgroup, which consisted of aCLs or anti-β2GPI only. Conclusion: Our study demonstrates the heterogeneity of aPL-related clinical manifestations and laboratory profiles in a multicenter international cohort. Within single aPL positivity, LAC may be a major contributor to clinical events. Future prospective analyses, using standardized core laboratory aPL tests, will help clarify aPL risk profiles and improve risk stratification.
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U2 - 10.1002/acr.24468
DO - 10.1002/acr.24468
M3 - Article
C2 - 32986935
AN - SCOPUS:85123784685
SN - 2151-464X
VL - 74
SP - 324
EP - 335
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 2
ER -