胰腺癌免疫微环境特点与相关免疫治疗策略

Translated title of the contribution: Characteristics of pancreatic ductal adenocarcinoma immune microenvironment and related immunotherapy strategies

Meng Yuan, Sadulla Abuduhaibaier, Siqian Ren, Lei Zheng, Chunhui Yuan

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic ductal adenocarcinoma is one of the common malignant tumors of the digestive tract. It has the characteristics of strong occlusion, aggressiveness, easy metastasis, and resistance to radiotherapy and chemotherapy. Therefore, its five-year survival rate is extremely low, with a rate of less than 8%. Looking for a new treatment is an urgent need to improve the prognosis of pancreatic ductal adenocarcinoma. In recent years, a large number of clinical trials have been carried out, such as immune checkpoint inhibitors, monoclonal antibodies to important antigens, and immune cell therapy. However, it is disappointing that no satisfactory clinical benefits have been achieved. The special microenvironment of pancreatic cancer nests makes immunotherapy not as effective as other malignant tumors. This article introduces the characteristics of the suppressive immune microenvironment of pancreatic cancer and the latest clinical studies of different types of immunotherapy at home and abroad, and analyzes the mechanisms and potentials of combined treatment based on the characteristics of the immune microenvironment.

Translated title of the contributionCharacteristics of pancreatic ductal adenocarcinoma immune microenvironment and related immunotherapy strategies
Original languageChinese (Traditional)
Pages (from-to)831-835
Number of pages5
JournalNational Medical Journal of China
Volume101
Issue number12
DOIs
StatePublished - Mar 30 2021

Keywords

  • Combined modality therapy
  • Immunotherapy
  • Pancreatic neoplasm
  • Tumor microenvironment

ASJC Scopus subject areas

  • Medicine(all)

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