Abstract
Background: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. Objective: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. Methods: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012. The association between MMAs and demographic variables was analyzed using mixed-effects logistic regression. Odds ratios (ORs) were calculated per 5-year age increments. Results: MMAs were observed in 338/2872 eyes (11.7%) of 232/1445 participants (16.1%). The most common abnormalities identified, included drusen (6.0%), epiretinal membrane (ERM; 5.5%), and microcystoid macular pathology (MMP; 1.9%). Overall, patients with MMAs were older (OR: 1.79, p = 5 × 10–5) and more likely to be males (OR: 2.45, p = 0.014). In particular, advancing age was associated with higher risk of drusen and ERM (OR: 1.80 and 4.26, p = 2 × 10–5 and 7 × 10–3, respectively). MMP prevalence declined with age (OR: 0.73, p = 0.015) and was associated with African-American ethnicity (OR: 15.0, p = 5 × 10–5). Conclusion: Unexpected or incidental MMAs are common in patients assessed with OCT in neuroimmunology practice, emphasizing the importance of comprehensive OCT image review for risk stratification and appropriate ophthalmology referral.
| Original language | English (US) |
|---|---|
| Journal | Multiple Sclerosis Journal |
| DOIs | |
| State | Accepted/In press - Nov 1 2017 |
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Keywords
- drusen
- epiretinal membrane
- microcystoid macular pathology
- Multiple sclerosis
- neuromyelitis optica
- optical coherence tomography
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Characteristics of morphologic macular abnormalities in neuroimmunology practice. / Al-Louzi, Omar; Sotirchos, Elias S.; Vidal-Jordana, Angela; Beh, Shin C.; Button, Julia; Ying, Howard S.; Balcer, Laura J.; Frohman, Elliot M.; Saidha, Shiv; Calabresi, Peter; Newsome, Scott.
In: Multiple Sclerosis Journal, 01.11.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characteristics of morphologic macular abnormalities in neuroimmunology practice
AU - Al-Louzi, Omar
AU - Sotirchos, Elias S.
AU - Vidal-Jordana, Angela
AU - Beh, Shin C.
AU - Button, Julia
AU - Ying, Howard S.
AU - Balcer, Laura J.
AU - Frohman, Elliot M.
AU - Saidha, Shiv
AU - Calabresi, Peter
AU - Newsome, Scott
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. Objective: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. Methods: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012. The association between MMAs and demographic variables was analyzed using mixed-effects logistic regression. Odds ratios (ORs) were calculated per 5-year age increments. Results: MMAs were observed in 338/2872 eyes (11.7%) of 232/1445 participants (16.1%). The most common abnormalities identified, included drusen (6.0%), epiretinal membrane (ERM; 5.5%), and microcystoid macular pathology (MMP; 1.9%). Overall, patients with MMAs were older (OR: 1.79, p = 5 × 10–5) and more likely to be males (OR: 2.45, p = 0.014). In particular, advancing age was associated with higher risk of drusen and ERM (OR: 1.80 and 4.26, p = 2 × 10–5 and 7 × 10–3, respectively). MMP prevalence declined with age (OR: 0.73, p = 0.015) and was associated with African-American ethnicity (OR: 15.0, p = 5 × 10–5). Conclusion: Unexpected or incidental MMAs are common in patients assessed with OCT in neuroimmunology practice, emphasizing the importance of comprehensive OCT image review for risk stratification and appropriate ophthalmology referral.
AB - Background: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. Objective: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. Methods: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012. The association between MMAs and demographic variables was analyzed using mixed-effects logistic regression. Odds ratios (ORs) were calculated per 5-year age increments. Results: MMAs were observed in 338/2872 eyes (11.7%) of 232/1445 participants (16.1%). The most common abnormalities identified, included drusen (6.0%), epiretinal membrane (ERM; 5.5%), and microcystoid macular pathology (MMP; 1.9%). Overall, patients with MMAs were older (OR: 1.79, p = 5 × 10–5) and more likely to be males (OR: 2.45, p = 0.014). In particular, advancing age was associated with higher risk of drusen and ERM (OR: 1.80 and 4.26, p = 2 × 10–5 and 7 × 10–3, respectively). MMP prevalence declined with age (OR: 0.73, p = 0.015) and was associated with African-American ethnicity (OR: 15.0, p = 5 × 10–5). Conclusion: Unexpected or incidental MMAs are common in patients assessed with OCT in neuroimmunology practice, emphasizing the importance of comprehensive OCT image review for risk stratification and appropriate ophthalmology referral.
KW - drusen
KW - epiretinal membrane
KW - microcystoid macular pathology
KW - Multiple sclerosis
KW - neuromyelitis optica
KW - optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85043310717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043310717&partnerID=8YFLogxK
U2 - 10.1177/1352458517741206
DO - 10.1177/1352458517741206
M3 - Article
C2 - 29125422
AN - SCOPUS:85043310717
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
ER -