TY - JOUR
T1 - Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome
AU - The Down Syndrome Cognition Project
AU - Channell, Marie Moore
AU - Hahn, Laura J.
AU - Rosser, Tracie C.
AU - Hamilton, Debra
AU - Frank-Crawford, Michelle A.
AU - Capone, George T.
AU - Sherman, Stephanie L.
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/9/15
Y1 - 2019/9/15
N2 - We examined autism spectrum disorder (ASD) risk in a large national sample of 203 individuals with Down syndrome, 6–25 years old, to determine the association of ASD risk with age, sex, IQ, adaptive behaviors, and maladaptive behaviors. We used a two-pronged approach by (1) considering ASD symptomatology continuously across the sample of individuals with DS and examining associations with each characteristic, and (2) dichotomizing our sample into high and low ASD risk groups and comparing groups on each characteristic. The pattern of results was largely similar across both types of analyses. ASD symptomatology/risk was negatively associated with IQ and adaptive behaviors and positively associated with certain types of maladaptive behaviors. Clinical implications for screening and therapeutic purposes are discussed.
AB - We examined autism spectrum disorder (ASD) risk in a large national sample of 203 individuals with Down syndrome, 6–25 years old, to determine the association of ASD risk with age, sex, IQ, adaptive behaviors, and maladaptive behaviors. We used a two-pronged approach by (1) considering ASD symptomatology continuously across the sample of individuals with DS and examining associations with each characteristic, and (2) dichotomizing our sample into high and low ASD risk groups and comparing groups on each characteristic. The pattern of results was largely similar across both types of analyses. ASD symptomatology/risk was negatively associated with IQ and adaptive behaviors and positively associated with certain types of maladaptive behaviors. Clinical implications for screening and therapeutic purposes are discussed.
KW - Autism spectrum disorder
KW - Down syndrome
KW - Intellectual disability
KW - Maladaptive behavior
KW - Psychiatric comorbidities
UR - http://www.scopus.com/inward/record.url?scp=85069967162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069967162&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04074-1
DO - 10.1007/s10803-019-04074-1
M3 - Article
C2 - 31124029
AN - SCOPUS:85069967162
SN - 0162-3257
VL - 49
SP - 3543
EP - 3556
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 9
ER -