Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves

Ahmad Masri, Vidyasagar Kalahasti, Saqer Alkharabsheh, Lars G. Svensson, Joseph F. Sabik, Eric E. Roselli, Donald Hammer, Douglas R. Johnston, Patrick Collier, L. Leonardo Rodriguez, Brian P. Griffin, Milind Y. Desai

Research output: Contribution to journalArticle

Abstract

Background: We sought to study the impact of surgical intervention on long-term outcomes in bicuspid aortic valve (BAV) patients who develop aortic valvular complications and/or have a concomitant aortopathy. Methods: We studied 1890 consecutive patients with BAV (age 50 ± 14 years; 75% men), evaluated in the time period 2003 to 2007. Clinical and imaging data were recorded. The endpoint was a composite of death or type A aortic dissection. Results: The mean left ventricular ejection fraction was 55% ± 8%; 31% had New York Heart Association class ≥ III aortic regurgitation, and 17% had mean aortic valve (AV) gradient ≥30 mm Hg. Dilated (≥4 cm) aortic root and ascending aorta were observed in 35% and 42% of patients, respectively. At 8.1 ± 2 years, 918 (49%) patients underwent surgery (883 had AV replacement and/or repair (± combination procedures), 471 with ascending aortic grafting (30 had isolated aortic grafting), and 171 (9%) events (169 deaths and 2 dissections) occurred; 0.4% was the 30-day mortality). On multivariable Cox survival analysis, increasing age (hazard ratio [HR] 1.06, 95% confidence interval [CI] [1.05-1.07]), increasing aortic root size (HR 1.32, 95% CI [1.07-1.65]), decreasing LV ejection fraction (HR 1.04, 95% CI [1.03-1.05]), and hyperlipidemia (HR 1.51, 95% CI [1.20-1.89]) had higher associated events, and surgery related to BAV (time-dependent covariate) (HR 0.44, 95% CI [0.31-0.70]) was associated with significantly lower events (all P <.01). Addition of surgery to BAV risk score (a composite of age, ≥moderate-severe aortic stenosis or regurgitation) and aortic root size further improved risk stratification (the C-statistic increased from 0.65 to 0.73; P = .01). Conclusions: Patients with BAV have a high prevalence of AV dysfunction and concomitant aortopathy. Undergoing surgery (AV replacement and/or repair ± AAR) was associated with a significantly lower incidence of death and/or dissection.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
DOIs
StateAccepted/In press - Sep 15 2015
Externally publishedYes

Fingerprint

Aortic Valve
Confidence Intervals
Dissection
Aortic Valve Insufficiency
Aortic Valve Stenosis
Survival Analysis
Hyperlipidemias
Stroke Volume
Aorta
Bicuspid Aortic Valve
Mortality
Incidence

Keywords

  • And outcomes
  • Aortopathy
  • Bicuspid aortic valve
  • Surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Masri, A., Kalahasti, V., Alkharabsheh, S., Svensson, L. G., Sabik, J. F., Roselli, E. E., ... Desai, M. Y. (Accepted/In press). Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves. Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2015.12.019

Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves. / Masri, Ahmad; Kalahasti, Vidyasagar; Alkharabsheh, Saqer; Svensson, Lars G.; Sabik, Joseph F.; Roselli, Eric E.; Hammer, Donald; Johnston, Douglas R.; Collier, Patrick; Rodriguez, L. Leonardo; Griffin, Brian P.; Desai, Milind Y.

In: Journal of Thoracic and Cardiovascular Surgery, 15.09.2015.

Research output: Contribution to journalArticle

Masri, A, Kalahasti, V, Alkharabsheh, S, Svensson, LG, Sabik, JF, Roselli, EE, Hammer, D, Johnston, DR, Collier, P, Rodriguez, LL, Griffin, BP & Desai, MY 2015, 'Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves', Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2015.12.019
Masri, Ahmad ; Kalahasti, Vidyasagar ; Alkharabsheh, Saqer ; Svensson, Lars G. ; Sabik, Joseph F. ; Roselli, Eric E. ; Hammer, Donald ; Johnston, Douglas R. ; Collier, Patrick ; Rodriguez, L. Leonardo ; Griffin, Brian P. ; Desai, Milind Y. / Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves. In: Journal of Thoracic and Cardiovascular Surgery. 2015.
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abstract = "Background: We sought to study the impact of surgical intervention on long-term outcomes in bicuspid aortic valve (BAV) patients who develop aortic valvular complications and/or have a concomitant aortopathy. Methods: We studied 1890 consecutive patients with BAV (age 50 ± 14 years; 75{\%} men), evaluated in the time period 2003 to 2007. Clinical and imaging data were recorded. The endpoint was a composite of death or type A aortic dissection. Results: The mean left ventricular ejection fraction was 55{\%} ± 8{\%}; 31{\%} had New York Heart Association class ≥ III aortic regurgitation, and 17{\%} had mean aortic valve (AV) gradient ≥30 mm Hg. Dilated (≥4 cm) aortic root and ascending aorta were observed in 35{\%} and 42{\%} of patients, respectively. At 8.1 ± 2 years, 918 (49{\%}) patients underwent surgery (883 had AV replacement and/or repair (± combination procedures), 471 with ascending aortic grafting (30 had isolated aortic grafting), and 171 (9{\%}) events (169 deaths and 2 dissections) occurred; 0.4{\%} was the 30-day mortality). On multivariable Cox survival analysis, increasing age (hazard ratio [HR] 1.06, 95{\%} confidence interval [CI] [1.05-1.07]), increasing aortic root size (HR 1.32, 95{\%} CI [1.07-1.65]), decreasing LV ejection fraction (HR 1.04, 95{\%} CI [1.03-1.05]), and hyperlipidemia (HR 1.51, 95{\%} CI [1.20-1.89]) had higher associated events, and surgery related to BAV (time-dependent covariate) (HR 0.44, 95{\%} CI [0.31-0.70]) was associated with significantly lower events (all P <.01). Addition of surgery to BAV risk score (a composite of age, ≥moderate-severe aortic stenosis or regurgitation) and aortic root size further improved risk stratification (the C-statistic increased from 0.65 to 0.73; P = .01). Conclusions: Patients with BAV have a high prevalence of AV dysfunction and concomitant aortopathy. Undergoing surgery (AV replacement and/or repair ± AAR) was associated with a significantly lower incidence of death and/or dissection.",
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AU - Masri, Ahmad

AU - Kalahasti, Vidyasagar

AU - Alkharabsheh, Saqer

AU - Svensson, Lars G.

AU - Sabik, Joseph F.

AU - Roselli, Eric E.

AU - Hammer, Donald

AU - Johnston, Douglas R.

AU - Collier, Patrick

AU - Rodriguez, L. Leonardo

AU - Griffin, Brian P.

AU - Desai, Milind Y.

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N2 - Background: We sought to study the impact of surgical intervention on long-term outcomes in bicuspid aortic valve (BAV) patients who develop aortic valvular complications and/or have a concomitant aortopathy. Methods: We studied 1890 consecutive patients with BAV (age 50 ± 14 years; 75% men), evaluated in the time period 2003 to 2007. Clinical and imaging data were recorded. The endpoint was a composite of death or type A aortic dissection. Results: The mean left ventricular ejection fraction was 55% ± 8%; 31% had New York Heart Association class ≥ III aortic regurgitation, and 17% had mean aortic valve (AV) gradient ≥30 mm Hg. Dilated (≥4 cm) aortic root and ascending aorta were observed in 35% and 42% of patients, respectively. At 8.1 ± 2 years, 918 (49%) patients underwent surgery (883 had AV replacement and/or repair (± combination procedures), 471 with ascending aortic grafting (30 had isolated aortic grafting), and 171 (9%) events (169 deaths and 2 dissections) occurred; 0.4% was the 30-day mortality). On multivariable Cox survival analysis, increasing age (hazard ratio [HR] 1.06, 95% confidence interval [CI] [1.05-1.07]), increasing aortic root size (HR 1.32, 95% CI [1.07-1.65]), decreasing LV ejection fraction (HR 1.04, 95% CI [1.03-1.05]), and hyperlipidemia (HR 1.51, 95% CI [1.20-1.89]) had higher associated events, and surgery related to BAV (time-dependent covariate) (HR 0.44, 95% CI [0.31-0.70]) was associated with significantly lower events (all P <.01). Addition of surgery to BAV risk score (a composite of age, ≥moderate-severe aortic stenosis or regurgitation) and aortic root size further improved risk stratification (the C-statistic increased from 0.65 to 0.73; P = .01). Conclusions: Patients with BAV have a high prevalence of AV dysfunction and concomitant aortopathy. Undergoing surgery (AV replacement and/or repair ± AAR) was associated with a significantly lower incidence of death and/or dissection.

AB - Background: We sought to study the impact of surgical intervention on long-term outcomes in bicuspid aortic valve (BAV) patients who develop aortic valvular complications and/or have a concomitant aortopathy. Methods: We studied 1890 consecutive patients with BAV (age 50 ± 14 years; 75% men), evaluated in the time period 2003 to 2007. Clinical and imaging data were recorded. The endpoint was a composite of death or type A aortic dissection. Results: The mean left ventricular ejection fraction was 55% ± 8%; 31% had New York Heart Association class ≥ III aortic regurgitation, and 17% had mean aortic valve (AV) gradient ≥30 mm Hg. Dilated (≥4 cm) aortic root and ascending aorta were observed in 35% and 42% of patients, respectively. At 8.1 ± 2 years, 918 (49%) patients underwent surgery (883 had AV replacement and/or repair (± combination procedures), 471 with ascending aortic grafting (30 had isolated aortic grafting), and 171 (9%) events (169 deaths and 2 dissections) occurred; 0.4% was the 30-day mortality). On multivariable Cox survival analysis, increasing age (hazard ratio [HR] 1.06, 95% confidence interval [CI] [1.05-1.07]), increasing aortic root size (HR 1.32, 95% CI [1.07-1.65]), decreasing LV ejection fraction (HR 1.04, 95% CI [1.03-1.05]), and hyperlipidemia (HR 1.51, 95% CI [1.20-1.89]) had higher associated events, and surgery related to BAV (time-dependent covariate) (HR 0.44, 95% CI [0.31-0.70]) was associated with significantly lower events (all P <.01). Addition of surgery to BAV risk score (a composite of age, ≥moderate-severe aortic stenosis or regurgitation) and aortic root size further improved risk stratification (the C-statistic increased from 0.65 to 0.73; P = .01). Conclusions: Patients with BAV have a high prevalence of AV dysfunction and concomitant aortopathy. Undergoing surgery (AV replacement and/or repair ± AAR) was associated with a significantly lower incidence of death and/or dissection.

KW - And outcomes

KW - Aortopathy

KW - Bicuspid aortic valve

KW - Surgery

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