Chapter 8: Role of kynurenine pathway in allergy

Hirokazu Kawasaki; Shau Ku Huang

doi:10.1007/978-3-319-11870-3_8

Chapter 8: Role of kynurenine pathway in allergy

Hirokazu Kawasaki, Shau Ku Huang

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

Original language	English (US)
Title of host publication	Targeting the Broadly Pathogenic Kynurenine Pathway
Publisher	Springer International Publishing
Pages	109-119
Number of pages	11
ISBN (Electronic)	9783319118703
ISBN (Print)	9783319118697
DOIs	https://doi.org/10.1007/978-3-319-11870-3_8
State	Published - Jan 1 2015

Keywords

Allergen-specifi c immunotherapy
Allergic diseases
Allergy
Aryl hydrocarbon receptor
Immune tolerance
Kynurenine
Mast cells

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine
General Neuroscience

Access to Document

10.1007/978-3-319-11870-3_8

Cite this

@inbook{450bedc1ad464a0bb62d3b6622176f31,

title = "Chapter 8: Role of kynurenine pathway in allergy",

abstract = "Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.",

keywords = "Allergen-specifi c immunotherapy, Allergic diseases, Allergy, Aryl hydrocarbon receptor, Immune tolerance, Kynurenine, Mast cells",

author = "Hirokazu Kawasaki and Huang, {Shau Ku}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-3-319-11870-3_8",

language = "English (US)",

isbn = "9783319118697",

pages = "109--119",

booktitle = "Targeting the Broadly Pathogenic Kynurenine Pathway",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Chapter 8

T2 - Role of kynurenine pathway in allergy

AU - Kawasaki, Hirokazu

AU - Huang, Shau Ku

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

AB - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

KW - Allergen-specifi c immunotherapy

KW - Allergic diseases

KW - Allergy

KW - Aryl hydrocarbon receptor

KW - Immune tolerance

KW - Kynurenine

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=84957033055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957033055&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-11870-3_8

DO - 10.1007/978-3-319-11870-3_8

M3 - Chapter

AN - SCOPUS:84957033055

SN - 9783319118697

SP - 109

EP - 119

BT - Targeting the Broadly Pathogenic Kynurenine Pathway

PB - Springer International Publishing

ER -

Chapter 8: Role of kynurenine pathway in allergy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this