Chapter 3 Role of SOCS in Allergic and Innate Immune Responses

Suzanne L. Cassel, Paul B Rothman

Research output: Contribution to journalArticle

Abstract

Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the response. Their individual functions are diverse, with stimulatory and inhibitory actions, with the resultant systemic immune response a summation of these actions. The frequently opposing effects of cytokines determine that the blockade of one results in the functional augmentation of the other. Thus, the differential regulation of cytokines profoundly influences the character of the immune response. The suppressor of cytokine signaling proteins are a family of molecules pivotal to this critical regulation. In this review, we will discuss their structural components and functions and our understanding of their impact on the systemic immune response.

Original languageEnglish (US)
Pages (from-to)49-76
Number of pages28
JournalAdvances in Immunology
Volume103
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Innate Immunity
Cytokines
Suppressor of Cytokine Signaling Proteins

Keywords

  • Asthma
  • Cytokine
  • Signaling
  • SOCS

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Chapter 3 Role of SOCS in Allergic and Innate Immune Responses. / Cassel, Suzanne L.; Rothman, Paul B.

In: Advances in Immunology, Vol. 103, 2009, p. 49-76.

Research output: Contribution to journalArticle

@article{71983c69852443c19f95c57fd84bfe53,
title = "Chapter 3 Role of SOCS in Allergic and Innate Immune Responses",
abstract = "Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the response. Their individual functions are diverse, with stimulatory and inhibitory actions, with the resultant systemic immune response a summation of these actions. The frequently opposing effects of cytokines determine that the blockade of one results in the functional augmentation of the other. Thus, the differential regulation of cytokines profoundly influences the character of the immune response. The suppressor of cytokine signaling proteins are a family of molecules pivotal to this critical regulation. In this review, we will discuss their structural components and functions and our understanding of their impact on the systemic immune response.",
keywords = "Asthma, Cytokine, Signaling, SOCS",
author = "Cassel, {Suzanne L.} and Rothman, {Paul B}",
year = "2009",
doi = "10.1016/S0065-2776(09)03003-X",
language = "English (US)",
volume = "103",
pages = "49--76",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Chapter 3 Role of SOCS in Allergic and Innate Immune Responses

AU - Cassel, Suzanne L.

AU - Rothman, Paul B

PY - 2009

Y1 - 2009

N2 - Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the response. Their individual functions are diverse, with stimulatory and inhibitory actions, with the resultant systemic immune response a summation of these actions. The frequently opposing effects of cytokines determine that the blockade of one results in the functional augmentation of the other. Thus, the differential regulation of cytokines profoundly influences the character of the immune response. The suppressor of cytokine signaling proteins are a family of molecules pivotal to this critical regulation. In this review, we will discuss their structural components and functions and our understanding of their impact on the systemic immune response.

AB - Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the response. Their individual functions are diverse, with stimulatory and inhibitory actions, with the resultant systemic immune response a summation of these actions. The frequently opposing effects of cytokines determine that the blockade of one results in the functional augmentation of the other. Thus, the differential regulation of cytokines profoundly influences the character of the immune response. The suppressor of cytokine signaling proteins are a family of molecules pivotal to this critical regulation. In this review, we will discuss their structural components and functions and our understanding of their impact on the systemic immune response.

KW - Asthma

KW - Cytokine

KW - Signaling

KW - SOCS

UR - http://www.scopus.com/inward/record.url?scp=69949191016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949191016&partnerID=8YFLogxK

U2 - 10.1016/S0065-2776(09)03003-X

DO - 10.1016/S0065-2776(09)03003-X

M3 - Article

C2 - 19755183

AN - SCOPUS:69949191016

VL - 103

SP - 49

EP - 76

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

ER -