Chapter 3 Role of SOCS in Allergic and Innate Immune Responses

Suzanne L. Cassel, Paul B. Rothman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the response. Their individual functions are diverse, with stimulatory and inhibitory actions, with the resultant systemic immune response a summation of these actions. The frequently opposing effects of cytokines determine that the blockade of one results in the functional augmentation of the other. Thus, the differential regulation of cytokines profoundly influences the character of the immune response. The suppressor of cytokine signaling proteins are a family of molecules pivotal to this critical regulation. In this review, we will discuss their structural components and functions and our understanding of their impact on the systemic immune response.

Original languageEnglish (US)
Title of host publicationAdvances in Immunology
EditorsF.W. Alt
Pages49-76
Number of pages28
DOIs
StatePublished - Sep 14 2009
Externally publishedYes

Publication series

NameAdvances in Immunology
Volume103
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Keywords

  • Asthma
  • Cytokine
  • Signaling
  • SOCS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Cassel, S. L., & Rothman, P. B. (2009). Chapter 3 Role of SOCS in Allergic and Innate Immune Responses. In F. W. Alt (Ed.), Advances in Immunology (pp. 49-76). (Advances in Immunology; Vol. 103). https://doi.org/10.1016/S0065-2776(09)03003-X