Chapter 3: Chemical Exchange Saturation Transfer (CEST) Contrast Agents

Giuseppe Ferrauto, Silvio Aime, Michael T Mcmahon, Janet R. Morrow, Eric M. Snyder, Alex Li, Robert Bartha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter considers the development of safe and sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI. CEST MRI is a contrast mechanism that enables the amplified detection of solutes based on the exchange of their labile protons with water. This chapter describes the general theory of CEST agents and their practical uses. Consideration is then given to the acquisition of CEST spectra, including instrumentation, sample conditions and data analysis, as well as the determination of the number of inner-sphere water molecules (q) for metal-based CEST complexes and proton exchange rates (kex). The preparation and characterization of paramagnetic micelles and liposomes is also discussed as well as the acquisition of CEST MR phantom images.

Original languageEnglish (US)
Title of host publicationNew Developments in NMR
PublisherRoyal Society of Chemistry
Pages243-317
Number of pages75
Volume2018-January
Edition13
DOIs
StatePublished - Jan 1 2018

Publication series

NameNew Developments in NMR
Number13
Volume2018-January
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

Cite this

Ferrauto, G., Aime, S., Mcmahon, M. T., Morrow, J. R., Snyder, E. M., Li, A., & Bartha, R. (2018). Chapter 3: Chemical Exchange Saturation Transfer (CEST) Contrast Agents. In New Developments in NMR (13 ed., Vol. 2018-January, pp. 243-317). (New Developments in NMR; Vol. 2018-January, No. 13). Royal Society of Chemistry. https://doi.org/10.1039/9781788010146-00243