Chapter 25 Neuronal responses to injury and aging: Lessons from animal models

Donald L. Price, Edward H. Koo, Sangram S. Sisodia, Lee J. Martin, Vassilis E. Koliatsos, Nancy A. Muma, Lary C. Walker, Linda C. Cork

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD), the most common type of adult-onset dementia, is characterized by a variety of brain abnormalities, including degeneration of certain populations of nerve cells, alterations in the neuronal cytoskeleton, and the abnormal deposition of amyloid withinbrain parenchyma. Pathogenetic processes that lead to these brain abnormalities are difficult to study in humans. Recently, investigators have begun to utilize animal models to examine some of the mechanisms that cause cellular/molecular alterations in transmitter systems, cytoskeletal elements, and APP. These investigations have helped to clarify issues related to the lesions that occur in aged humans and individuals with AD.

Original languageEnglish (US)
Pages (from-to)297-308
Number of pages12
JournalProgress in brain research
Volume86
Issue numberC
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Neuroscience(all)

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