Chapter 21 Plasticity of pain-related neuronal activity in the human thalamus

William S Anderson, S. Ohara, H. C. Lawson, R. D. Treede, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

Strokes and other forms of injury to the central nervous system cause changes in function because of the injuries themselves and indirectly because injuries cause expression of neural plasticity. Studies in humans undergoing neurosurgical procedures for implantation of electrodes for deep brain stimulation and for making lesions in the brain have contributed understanding of both normal and abnormal functions of the somatic sensory system. This chapter will specifically discuss the reorganization of the ventral caudal (Vc) sensory nucleus of the thalamus that occurs in connection with pain conditions after strokes and spinal cord injuries. It is shown that pain is associated with expression of neural plasticity that alters maps of noxious and innocuous stimulation in the thalamus and affect processing of sensory information. Results from studies of neural activity in the thalamus in humans will be compared with results from animal studies.

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalProgress in Brain Research
Volume157
DOIs
StatePublished - 2006

Fingerprint

Thalamus
Human Activities
Neuronal Plasticity
Pain
Wounds and Injuries
Stroke
Neurosurgical Procedures
Deep Brain Stimulation
Spinal Cord Injuries
Automatic Data Processing
Electrodes
Central Nervous System
Brain

Keywords

  • amputation
  • dystonia
  • neurophysiology
  • sensory reorganization
  • single neuron recordings.
  • thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chapter 21 Plasticity of pain-related neuronal activity in the human thalamus. / Anderson, William S; Ohara, S.; Lawson, H. C.; Treede, R. D.; Lenz, Frederick.

In: Progress in Brain Research, Vol. 157, 2006, p. 353-364.

Research output: Contribution to journalArticle

@article{4d7e00f7c4c24f1688829f45fbe2674b,
title = "Chapter 21 Plasticity of pain-related neuronal activity in the human thalamus",
abstract = "Strokes and other forms of injury to the central nervous system cause changes in function because of the injuries themselves and indirectly because injuries cause expression of neural plasticity. Studies in humans undergoing neurosurgical procedures for implantation of electrodes for deep brain stimulation and for making lesions in the brain have contributed understanding of both normal and abnormal functions of the somatic sensory system. This chapter will specifically discuss the reorganization of the ventral caudal (Vc) sensory nucleus of the thalamus that occurs in connection with pain conditions after strokes and spinal cord injuries. It is shown that pain is associated with expression of neural plasticity that alters maps of noxious and innocuous stimulation in the thalamus and affect processing of sensory information. Results from studies of neural activity in the thalamus in humans will be compared with results from animal studies.",
keywords = "amputation, dystonia, neurophysiology, sensory reorganization, single neuron recordings., thalamus",
author = "Anderson, {William S} and S. Ohara and Lawson, {H. C.} and Treede, {R. D.} and Frederick Lenz",
year = "2006",
doi = "10.1016/S0079-6123(06)57021-9",
language = "English (US)",
volume = "157",
pages = "353--364",
journal = "Progress in Brain Research",
issn = "0079-6123",
publisher = "Elsevier",

}

TY - JOUR

T1 - Chapter 21 Plasticity of pain-related neuronal activity in the human thalamus

AU - Anderson, William S

AU - Ohara, S.

AU - Lawson, H. C.

AU - Treede, R. D.

AU - Lenz, Frederick

PY - 2006

Y1 - 2006

N2 - Strokes and other forms of injury to the central nervous system cause changes in function because of the injuries themselves and indirectly because injuries cause expression of neural plasticity. Studies in humans undergoing neurosurgical procedures for implantation of electrodes for deep brain stimulation and for making lesions in the brain have contributed understanding of both normal and abnormal functions of the somatic sensory system. This chapter will specifically discuss the reorganization of the ventral caudal (Vc) sensory nucleus of the thalamus that occurs in connection with pain conditions after strokes and spinal cord injuries. It is shown that pain is associated with expression of neural plasticity that alters maps of noxious and innocuous stimulation in the thalamus and affect processing of sensory information. Results from studies of neural activity in the thalamus in humans will be compared with results from animal studies.

AB - Strokes and other forms of injury to the central nervous system cause changes in function because of the injuries themselves and indirectly because injuries cause expression of neural plasticity. Studies in humans undergoing neurosurgical procedures for implantation of electrodes for deep brain stimulation and for making lesions in the brain have contributed understanding of both normal and abnormal functions of the somatic sensory system. This chapter will specifically discuss the reorganization of the ventral caudal (Vc) sensory nucleus of the thalamus that occurs in connection with pain conditions after strokes and spinal cord injuries. It is shown that pain is associated with expression of neural plasticity that alters maps of noxious and innocuous stimulation in the thalamus and affect processing of sensory information. Results from studies of neural activity in the thalamus in humans will be compared with results from animal studies.

KW - amputation

KW - dystonia

KW - neurophysiology

KW - sensory reorganization

KW - single neuron recordings.

KW - thalamus

UR - http://www.scopus.com/inward/record.url?scp=33749628545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749628545&partnerID=8YFLogxK

U2 - 10.1016/S0079-6123(06)57021-9

DO - 10.1016/S0079-6123(06)57021-9

M3 - Article

VL - 157

SP - 353

EP - 364

JO - Progress in Brain Research

JF - Progress in Brain Research

SN - 0079-6123

ER -