Chapter 2: Production of NO - The l-arginine/NOS/NO System

Research output: Chapter in Book/Report/Conference proceedingChapter


Nitric oxide (NO) was the first molecule afforded the status of gasotransmitter or gaseous signaling molecule. The seminal work by Furchgott, Ignarro, and Murad established the vasoactive functions of NO as an endothelial-derived relaxation factor. This was followed by the identification and cloning of its biosynthetic enzymes and elucidation of its role as a signaling molecule both in peripheral tissues and in the brain, where it functions as a neurotransmitter. NO is synthesized endogenously from the amino acid arginine. In this chapter, we review the biogenesis of NO and its regulation at multiple levels.

Original languageEnglish (US)
Title of host publicationRSC Metallobiology
EditorsRui Wang
PublisherRoyal Society of Chemistry
Number of pages15
StatePublished - 2018

Publication series

NameRSC Metallobiology
ISSN (Print)2045-547X

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)


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