TY - JOUR
T1 - Chapter 2 Molecular aspects of hormone deficiency caused by Pit-1 gene mutations
AU - Cohen, Laurie E.
AU - Radovick, Sally
AU - Wondisford, Fredric E.
PY - 1997
Y1 - 1997
N2 - Pit-1 functions in the development of the GH-secreting somatotrophs, the Prl-secreting lactotrophs, and a population of the TSHß-secreting thyrotrophs. Pit-1 activates GH and Prl gene expression and regulates Prl and TSHß gene expression through binding to sites on these target genes and interacting with a wide number of additional factors. Pit-1 also regulates its own gene expression, although it is not responsible for initial activation of its gene. Naturally occurring murine and human Pit-1 gene mutations have been crucial in elucidating Pit-1 structure-function relationships.
AB - Pit-1 functions in the development of the GH-secreting somatotrophs, the Prl-secreting lactotrophs, and a population of the TSHß-secreting thyrotrophs. Pit-1 activates GH and Prl gene expression and regulates Prl and TSHß gene expression through binding to sites on these target genes and interacting with a wide number of additional factors. Pit-1 also regulates its own gene expression, although it is not responsible for initial activation of its gene. Naturally occurring murine and human Pit-1 gene mutations have been crucial in elucidating Pit-1 structure-function relationships.
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U2 - 10.1016/S1569-2566(97)80033-6
DO - 10.1016/S1569-2566(97)80033-6
M3 - Article
AN - SCOPUS:77957057418
SN - 1569-2566
VL - 1
SP - 31
EP - 50
JO - Advances in Molecular and Cellular Endocrinology
JF - Advances in Molecular and Cellular Endocrinology
IS - C
ER -