Chapter 15 Seizures in Pregnancy. Diagnosis and Management

Robert L. Beach, Peter W Kaplan

Research output: Contribution to journalArticle

Abstract

Most seizures during pregnancy occur in women who already have epilepsy. During pregnancy most women will continue their previous level of seizure control, although 15-30% may experience an increase in seizures. Pregnancy-induced changes in antiepileptic drug pharmacokinetics are a major factor affecting changes in seizure control during pregnancy, although compliance is also a significant factor. Status epilepticus occurs in only 1-2% of pregnancies, and if treated appropriately and aggressively carries a fairly low risk of morbidity and mortality. Structural and metabolic changes may precipitate new-onset seizures during pregnancy. The structural causes include intracranial hemorrhage of multiple types, cerebral venous sinus thrombosis, and ischemic stroke. Metabolic causes include hyperemesis gravidarum; acute hepatitis (due to fatty liver of pregnancy or viral hepatitis); metabolic diseases, such as acute intermittent porphyria; infections, such as malaria; and eclampsia.

Original languageEnglish (US)
Pages (from-to)259-271
Number of pages13
JournalInternational Review of Neurobiology
Volume83
DOIs
StatePublished - 2008

Fingerprint

Seizures
Pregnancy
Hepatitis
Hyperemesis Gravidarum
Intracranial Sinus Thrombosis
Acute Intermittent Porphyria
Eclampsia
Status Epilepticus
Intracranial Hemorrhages
Metabolic Diseases
Fatty Liver
Venous Thrombosis
Anticonvulsants
Malaria
Compliance
Epilepsy
Pharmacokinetics
Stroke
Morbidity
Mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Chapter 15 Seizures in Pregnancy. Diagnosis and Management. / Beach, Robert L.; Kaplan, Peter W.

In: International Review of Neurobiology, Vol. 83, 2008, p. 259-271.

Research output: Contribution to journalArticle

@article{75c70b614b6b4b06854765bcba6f1bc2,
title = "Chapter 15 Seizures in Pregnancy. Diagnosis and Management",
abstract = "Most seizures during pregnancy occur in women who already have epilepsy. During pregnancy most women will continue their previous level of seizure control, although 15-30{\%} may experience an increase in seizures. Pregnancy-induced changes in antiepileptic drug pharmacokinetics are a major factor affecting changes in seizure control during pregnancy, although compliance is also a significant factor. Status epilepticus occurs in only 1-2{\%} of pregnancies, and if treated appropriately and aggressively carries a fairly low risk of morbidity and mortality. Structural and metabolic changes may precipitate new-onset seizures during pregnancy. The structural causes include intracranial hemorrhage of multiple types, cerebral venous sinus thrombosis, and ischemic stroke. Metabolic causes include hyperemesis gravidarum; acute hepatitis (due to fatty liver of pregnancy or viral hepatitis); metabolic diseases, such as acute intermittent porphyria; infections, such as malaria; and eclampsia.",
author = "Beach, {Robert L.} and Kaplan, {Peter W}",
year = "2008",
doi = "10.1016/S0074-7742(08)00015-9",
language = "English (US)",
volume = "83",
pages = "259--271",
journal = "International Review of Neurobiology",
issn = "0074-7742",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Chapter 15 Seizures in Pregnancy. Diagnosis and Management

AU - Beach, Robert L.

AU - Kaplan, Peter W

PY - 2008

Y1 - 2008

N2 - Most seizures during pregnancy occur in women who already have epilepsy. During pregnancy most women will continue their previous level of seizure control, although 15-30% may experience an increase in seizures. Pregnancy-induced changes in antiepileptic drug pharmacokinetics are a major factor affecting changes in seizure control during pregnancy, although compliance is also a significant factor. Status epilepticus occurs in only 1-2% of pregnancies, and if treated appropriately and aggressively carries a fairly low risk of morbidity and mortality. Structural and metabolic changes may precipitate new-onset seizures during pregnancy. The structural causes include intracranial hemorrhage of multiple types, cerebral venous sinus thrombosis, and ischemic stroke. Metabolic causes include hyperemesis gravidarum; acute hepatitis (due to fatty liver of pregnancy or viral hepatitis); metabolic diseases, such as acute intermittent porphyria; infections, such as malaria; and eclampsia.

AB - Most seizures during pregnancy occur in women who already have epilepsy. During pregnancy most women will continue their previous level of seizure control, although 15-30% may experience an increase in seizures. Pregnancy-induced changes in antiepileptic drug pharmacokinetics are a major factor affecting changes in seizure control during pregnancy, although compliance is also a significant factor. Status epilepticus occurs in only 1-2% of pregnancies, and if treated appropriately and aggressively carries a fairly low risk of morbidity and mortality. Structural and metabolic changes may precipitate new-onset seizures during pregnancy. The structural causes include intracranial hemorrhage of multiple types, cerebral venous sinus thrombosis, and ischemic stroke. Metabolic causes include hyperemesis gravidarum; acute hepatitis (due to fatty liver of pregnancy or viral hepatitis); metabolic diseases, such as acute intermittent porphyria; infections, such as malaria; and eclampsia.

UR - http://www.scopus.com/inward/record.url?scp=53049102029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53049102029&partnerID=8YFLogxK

U2 - 10.1016/S0074-7742(08)00015-9

DO - 10.1016/S0074-7742(08)00015-9

M3 - Article

C2 - 18929087

AN - SCOPUS:53049102029

VL - 83

SP - 259

EP - 271

JO - International Review of Neurobiology

JF - International Review of Neurobiology

SN - 0074-7742

ER -