Chapter 15 Seizures in Pregnancy. Diagnosis and Management

Robert L. Beach, Peter W. Kaplan

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Most seizures during pregnancy occur in women who already have epilepsy. During pregnancy most women will continue their previous level of seizure control, although 15-30% may experience an increase in seizures. Pregnancy-induced changes in antiepileptic drug pharmacokinetics are a major factor affecting changes in seizure control during pregnancy, although compliance is also a significant factor. Status epilepticus occurs in only 1-2% of pregnancies, and if treated appropriately and aggressively carries a fairly low risk of morbidity and mortality. Structural and metabolic changes may precipitate new-onset seizures during pregnancy. The structural causes include intracranial hemorrhage of multiple types, cerebral venous sinus thrombosis, and ischemic stroke. Metabolic causes include hyperemesis gravidarum; acute hepatitis (due to fatty liver of pregnancy or viral hepatitis); metabolic diseases, such as acute intermittent porphyria; infections, such as malaria; and eclampsia.

Original languageEnglish (US)
Title of host publicationEpilepsy in Women The Scientific Basis for Clinical Management
EditorsBarry Gidal, Cynthia Harden
Pages259-271
Number of pages13
DOIs
StatePublished - 2008

Publication series

NameInternational Review of Neurobiology
Volume83
ISSN (Print)0074-7742

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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