Chapter 13 Tumor-Specific Liposomal Drug Release Mediated by Liposomase

Ian Cheong, Shibin Zhou

Research output: Contribution to journalReview article

Abstract

Despite the large arsenal of anticancer agents currently available and recent efforts in developing molecularly targeted therapies, the prognosis for many solid cancers remains dismal. A major obstacle to successful cancer therapy is the limited specificity of most anticancer agents. One approach to this problem is to construct drug carriers that preferentially accumulate at the cancer site, thus targeting otherwise nonselective cytotoxic chemotherapeutic agents to cancer cells. Liposomes stand out in this regard as the most successful drug carrier that has been approved for clinical use. Currently, most clinical liposomal formulations involve the use of PEGylated phospholipids that help prolong their residence time in the systemic circulation. Paradoxically, the robustness of these long-circulating formulations also obstructs the release of their payloads at the cancer site. This chapter describes a recently discovered bacterial protein capable of targeted liposome disruption within tumors.

Original languageEnglish (US)
Pages (from-to)251-265
Number of pages15
JournalMethods in enzymology
Volume465
Issue numberC
DOIs
StatePublished - Dec 14 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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