Chaperone-mediated autophagy targets hypoxia-inducible factor-1β(HIF- 1β) for lysosomal degradation

Maimon E. Hubbi, Hongxia Hu, Kshitiz, Ishrat Ahmed, Andre Levchenko, Gregg L. Semenza

Research output: Contribution to journalArticle

Abstract

Background: Regulation of hypoxia-inducible factor-1 (HIF-1) is focused on proteasomal degradation of the HIF-1β subunit. Results: Pharmacological and genetic approaches establish that HIF-1βbinds to effectors of chaperone-mediated autophagy (CMA) and is targeted for lysosomal degradation. Conclusion: CMA targets HIF-1βfor lysosomal degradation. Significance: Lysosomal degradation of HIF-1βrepresents a novel mechanism of HIF-1 regulation and a potential therapeutic target.

Original languageEnglish (US)
Pages (from-to)10703-10714
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number15
DOIs
StatePublished - Apr 12 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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