Changing diagnostic concepts of alzheimer's disease

Guy M. McKhann, Marilyn S. Albert, Reisa A. Sperling

Research output: Chapter in Book/Report/Conference proceedingChapter


Diagnostic concepts of Alzheimer's disease have evolved over the past few decades. There is now a consensus that Alzheimer's disease pathophysiological processes develop slowly over many years and, thus, it is appropriate for diagnostic approaches to consider the continuum of disease, from presymptomatic individuals, to those with mild cognitive impairment, to patients with dementia. Several diagnostic criteria have been proposed using this perspective. This chapter focuses on the National Institute on Aging - Alzheimer's Association criteria published in 2011 and compares them with two other diagnostic criteria - those proposed by the International Working Group and those proposed by the DSM-5 workgroup.

Original languageEnglish (US)
Title of host publicationAlzheimer's Disease
Subtitle of host publicationModernizing Concept, Biological Diagnosis and Therapy
PublisherS. Karger AG
Number of pages7
ISBN (Electronic)9783805598033
ISBN (Print)9783805598026
StatePublished - Apr 23 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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